Takekura N, Yasui W, Yoshida K, Tsujino T, Nakayama H, Kameda T, Yokozaki H, Nishimura Y, Ito H, Tahara E
First Department of Pathology, Hiroshima University School of Medicine, Japan.
Int J Cancer. 1990 May 15;45(5):847-51. doi: 10.1002/ijc.2910450510.
We examined pp60c-src protein kinase activity in human gastric carcinoma cell lines and gastric carcinoma tissues as well as normal mucosa. pp60c-src kinase activity was detected in all 5 carcinoma cell lines at various levels. Of 16 gastric carcinoma tissues, 8 showed higher pp60c-src kinase activity in tumor tissues than in corresponding normal mucosa. However, the levels of expression of pp60c-src detected by Western blotting were not always consistent with the activities of pp60c-src protein kinase. These findings suggest that the increase in pp60c-src protein kinase activity might be brought about by post-translational changes.
