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I型磷脂酰肌醇激酶活性与人类pp60c-src的突变激活形式的关联。

Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src.

作者信息

Chan T O, Tanaka A, Bjorge J D, Fujita D J

机构信息

Department of Medical Biochemistry, University of Calgary Medical Sciences Centre, Alberta, Canada.

出版信息

Mol Cell Biol. 1990 Jun;10(6):3280-3. doi: 10.1128/mcb.10.6.3280-3283.1990.

DOI:10.1128/mcb.10.6.3280-3283.1990
PMID:2160600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC360699/
Abstract

Chicken embryo fibroblast cells overexpressing activated mutant forms of human pp60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine protein kinase activity and not with absolute levels of pp60c-src. Our results suggest that a linkage exists between certain forms of pp60c-src and the PI signal transduction pathway.

摘要

过表达人pp60c-src激活突变形式的鸡胚成纤维细胞，而非过表达正常人pp60c-src的细胞，表现出与pp60c-src相关的高水平I型磷脂酰肌醇（PI）激酶活性。PI激酶活性水平与src酪氨酸蛋白激酶活性呈正相关，而与pp60c-src的绝对水平无关。我们的结果表明，特定形式的pp60c-src与PI信号转导途径之间存在联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68d0/360699/a730e8a7aeef/molcellb00042-0852-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68d0/360699/c65b76a46cb9/molcellb00042-0851-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68d0/360699/a730e8a7aeef/molcellb00042-0852-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68d0/360699/c65b76a46cb9/molcellb00042-0851-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68d0/360699/a730e8a7aeef/molcellb00042-0852-a.jpg

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