通过铜（I）催化的炔烃和 1-碘炔烃的氨化反应合成 7-氮杂-5-去氮嘌呤类似物。
Synthesis of 7-aza-5-deazapurine analogues via copper(I)-catalyzed hydroamination of alkynes and 1-iodoalkynes.
机构信息
Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
出版信息
J Org Chem. 2010 Dec 17;75(24):8662-5. doi: 10.1021/jo1016376. Epub 2010 Nov 24.
Abstract
A new method for the synthesis of dihydroimidazo[1,2-a][1,3,5]triazin-4(6H)-ones via copper(I)-catalyzed hydroamination was developed. In addition, for the first time, iodoalkynes were shown to participate in the copper(I)-catalyzed intramolecular hydroamination reaction with exclusive formation of E-isomers.
摘要
一种通过铜（I）催化的氨化反应合成二氢咪唑并[1,2-a][1,3,5]三嗪-4(6H)-酮的新方法被开发出来。此外，碘炔首次被证明可以参与铜（I）催化的分子内氨化反应，并且只生成 E-异构体。
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