Center for Alcohol and Addiction Studies, Brown University, Box G-S121-5, Providence, RI 02912, USA.
Nicotine Tob Res. 2011 Feb;13(2):146-50. doi: 10.1093/ntr/ntq213. Epub 2010 Nov 24.
The question of whether abstinence during the months following a planned quit attempt exacerbates or improves depressive symptoms is an important clinical issue. Extant research has primarily modeled between-person covariation between postquit abstinence and depressive symptom trajectories. However, this approach cannot account for potential third variables between participants that may affect both smoking and depression. Accordingly, the current study examined within-person covariation between time-varying abstinence and depressive symptom in a multilevel model (MLM), which allowed for transitions between smoking statuses within a participant.
Participants were 236 heavy drinking smokers in a randomized clinical trial testing the efficacy of incorporating brief alcohol intervention into smoking cessation treatment. Depressive symptoms and biochemically verified abstinence were assessed 1 week prior to and 2, 8, 16, and 26 weeks after quit date.
MLMs indicated a slight increase in depressive symptoms over time in the sample as a whole. However, there was an inverse relation between time-varying abstinence (vs. smoking) and concurrent level of depressive symptoms, indicating that transitions from smoking to abstinence within individuals were associated with reductions in depressive symptoms.
During the first 6 months following a planned quit attempt, being abstinent in a particular week appears to be associated with lower levels of concurrent depressive symptoms. These results are not concordant with the view that intentional smoking abstinence exacerbates depressive symptoms. Efforts to promote smoking cessation should highlight that individuals are likely to feel more rather than less psychologically healthy when they successfully quit smoking.
在计划戒烟后的几个月内是否保持禁欲状态会加剧还是改善抑郁症状是一个重要的临床问题。现有研究主要在个体间模型中模拟了戒烟后禁欲状态和抑郁症状轨迹之间的共变关系。然而,这种方法无法解释可能影响吸烟和抑郁的参与者之间的潜在第三变量。因此,本研究在多层次模型(MLM)中检查了随时间变化的禁欲状态和抑郁症状之间的个体内共变关系,该模型允许参与者在吸烟状态之间进行转换。
参与者是一项随机临床试验中的 236 名重度饮酒吸烟者,该试验测试了将简短酒精干预纳入戒烟治疗中的效果。在戒烟日期前 1 周以及戒烟后 2、8、16 和 26 周,评估了抑郁症状和生物化学验证的禁欲状态。
MLM 表明,整个样本的抑郁症状随时间略有增加。然而,在时间变化的禁欲状态(与吸烟相比)与同时存在的抑郁症状水平之间存在反比关系,这表明个体内从吸烟到禁欲的转变与抑郁症状的减轻有关。
在计划戒烟后的头 6 个月内,在特定的一周内保持禁欲状态似乎与同时存在的抑郁症状水平较低有关。这些结果与故意吸烟禁欲会加剧抑郁症状的观点不一致。促进戒烟的努力应该强调,当个体成功戒烟时,他们可能会感到更健康,而不是更不健康。