血清可溶性 CD163 可预测普通人群 2 型糖尿病的发病风险。
Serum soluble CD163 predicts risk of type 2 diabetes in the general population.
机构信息
Department of Clinical Biochemistry, Aarhus University Hospital, Århus Sygehus, Denmark.
出版信息
Clin Chem. 2011 Feb;57(2):291-7. doi: 10.1373/clinchem.2010.154724. Epub 2010 Nov 24.
BACKGROUND
Activation of adipose tissue macrophages with concomitant low-grade inflammation is believed to play a central role in the development of type 2 diabetes. We tested whether a new macrophage-derived biomarker, soluble CD163 (sCD163), identifies at-risk individuals before overt disease has developed.
METHODS
A prospective cohort study of 8849 study participants from the general population, the Copenhagen City Heart Study, was followed for 18 years for incidence of type 2 diabetes. Risk of disease was calculated according to age- and sex-adjusted percentile categories of serum sCD163 concentrations: 0%-33%, 34%-66%, 67%-90%, 91%-95%, and 96%-100%.
RESULTS
A total of 568 participants developed type 2 diabetes. The cumulative incidence increased with increasing baseline sCD163 (trend P < 0.001), and sCD163 was strongly associated with known risk factors such as physical inactivity, body mass index, C-reactive protein, and triglycerides (all P < 0.001). Multifactorially adjusted hazard ratios for type 2 diabetes were 1.4 (95% CI, 1.0-1.9), 2.4 (1.8-3.2), 3.8 (2.6-5.5), and 5.2 (3.6-7.6) for categories 34%-66%, 67%-90%, 91%-95%, and 96%-100%, respectively, vs the 0%-33% category. In overweight men 50-70 and >70 years of age, serum sCD163 concentrations in the top 5% group predicted an absolute 10-year risk of type 2 diabetes of 29% and 36% vs 7% and 8% in the lowest percentile group. Equivalent values in women were 19% and 24% vs 4% and 5%.
CONCLUSIONS
Increased concentrations of sCD163 predict increased risk of type 2 diabetes in the general population and may be useful for identification of high-risk overweight individuals.
背景
脂肪组织巨噬细胞的激活伴有低度炎症，被认为在 2 型糖尿病的发展中起核心作用。我们检测了一种新的巨噬细胞衍生生物标志物可溶性 CD163（sCD163），以确定在明显疾病发生之前处于危险状态的个体。
方法
一项来自普通人群的前瞻性队列研究，哥本哈根城市心脏研究，对 8849 名研究参与者进行了 18 年的 2 型糖尿病发病情况随访。根据血清 sCD163 浓度的年龄和性别调整百分位数类别计算疾病风险：0%-33%、34%-66%、67%-90%、91%-95%和 96%-100%。
结果
共有 568 名参与者发生 2 型糖尿病。随着基线 sCD163 的增加，累积发病率呈上升趋势（趋势 P<0.001），sCD163 与已知的风险因素如体力活动不足、体重指数、C 反应蛋白和甘油三酯密切相关（均 P<0.001）。经多因素调整的 2 型糖尿病的危险比为 1.4（95%可信区间，1.0-1.9）、2.4（1.8-3.2）、3.8（2.6-5.5）和 5.2（3.6-7.6），分别对应 34%-66%、67%-90%、91%-95%和 96%-100%的类别，而 0%-33%的类别为 1.0。在 50-70 岁和>70 岁的超重男性中，血清 sCD163 浓度在前 5%组的 10 年绝对 2 型糖尿病风险预测值为 29%和 36%，而最低百分位组为 7%和 8%。女性的相应值为 19%和 24%，而 4%和 5%。
结论
sCD163 浓度的增加预测了普通人群中 2 型糖尿病的风险增加，并且可能有助于识别高风险超重个体。
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