Rojo-Martínez Gemma, Maymó-Masip Elsa, Rodríguez M Mar, Solano Esther, Goday Albert, Soriguer Federico, Valdés Sergio, Chaves Felipe Javier, Delgado Elías, Colomo Natalia, Hernández Pilar, Vendrell Joan, Chacón Matilde R
UGCI de Endocrinología y Nutrición, Instituto de Biomedicina de Málaga (IBIMA), Hospital Regional Universitario, Málaga, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas CIBERDEM, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas CIBERDEM, Barcelona, Spain; Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain.
PLoS One. 2014 Jun 30;9(6):e101250. doi: 10.1371/journal.pone.0101250. eCollection 2014.
Serum levels of soluble TNF-like weak inducer of apoptosis (sTWEAK) and its scavenger receptor CD163 (sCD163) have been linked to insulin resistance. We analysed the usefulness of these cytokines as biomarkers of type 2 diabetes in a Spanish cohort, together with their relationship to food consumption in the setting of the Di@bet.es study.
This is a cross-sectional, matched case-control study of 514 type 2 diabetes subjects and 517 controls with a Normal Oral Glucose Tolerance Test (NOGTT), using data from the Di@bet.es study. Study variables included clinical and demographic structured survey, food frequency questionnaire and physical examination. Serum concentrations of sTWEAK and sCD163 were measured by ELISA. Linear regression analysis determined which variables were related to sTWEAK and sCD163 levels. Logistic regression analysis was used to estimate odd ratios of presenting type 2 diabetes.
sCD163 concentrations and sCD163/sTWEAK ratio were 11.0% and 15.0% higher, respectively, (P<0.001) in type 2 diabetes than in controls. Following adjustment for various confounders, the OR for presenting type 2 diabetes in subjects in the highest vs the lowest tertile of sCD163 was [(OR), 2,01 (95%CI, 1,46-2,97); P for trend <0.001]. Coffee and red wine consumption was negatively associated with serum levels of sCD163 (P = 0.0001 and; P = 0.002 for coffee and red wine intake, respectively).
High circulating levels of sCD163 are associated with type 2 diabetes in the Spanish population. The association between coffee and red wine intake and these biomarkers deserves further study to confirm its potential role in type 2 diabetes.
血清可溶性肿瘤坏死因子样凋亡微弱诱导剂（sTWEAK）及其清道夫受体CD163（sCD163）水平与胰岛素抵抗有关。在西班牙队列中，我们分析了这些细胞因子作为2型糖尿病生物标志物的效用，以及它们在Di@bet.es研究背景下与食物摄入的关系。
这是一项横断面、匹配病例对照研究，纳入了514例2型糖尿病患者和517例口服葡萄糖耐量试验正常（NOGTT）的对照，使用的是Di@bet.es研究的数据。研究变量包括临床和人口统计学结构化调查、食物频率问卷和体格检查。采用酶联免疫吸附测定法（ELISA）测量血清sTWEAK和sCD163浓度。线性回归分析确定哪些变量与sTWEAK和sCD163水平相关。采用逻辑回归分析估计患2型糖尿病的比值比。
2型糖尿病患者的sCD163浓度和sCD163/sTWEAK比值分别比对照组高11.0%和15.0%（P<0.001）。在对各种混杂因素进行调整后，sCD163最高三分位数与最低三分位数的受试者患2型糖尿病的比值比为[比值比（OR），2.01（95%置信区间，1.46 - 2.97）；趋势P<0.001]。咖啡和红酒的摄入量与血清sCD163水平呈负相关（咖啡和红酒摄入量的P值分别为0.0001和0.002）。
西班牙人群中循环sCD163水平升高与2型糖尿病有关。咖啡和红酒摄入量与这些生物标志物之间的关联值得进一步研究，以证实其在2型糖尿病中的潜在作用。
