Lázničková Petra, Bendíčková Kamila, Kepák Tomáš, Frič Jan
International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Front Aging. 2021 Jul 19;2:708788. doi: 10.3389/fragi.2021.708788. eCollection 2021.
The population of childhood cancer survivors (CCS) has grown rapidly in recent decades. Although cured of their original malignancy, these individuals are at increased risk of serious late effects, including age-associated complications. An impaired immune system has been linked to the emergence of these conditions in the elderly and CCS, likely due to senescent immune cell phenotypes accompanied by low-grade inflammation, which in the elderly is known as "inflammaging." Whether these observations in the elderly and CCS are underpinned by similar mechanisms is unclear. If so, existing knowledge on immunosenescent phenotypes and inflammaging might potentially serve to benefit CCS. We summarize recent findings on the immune changes in CCS and the elderly, and highlight the similarities and identify areas for future research. Improving our understanding of the underlying mechanisms and immunosenescent markers of accelerated immune aging might help us to identify individuals at increased risk of serious health complications.
近几十年来，儿童癌症幸存者（CCS）的数量迅速增长。尽管他们最初的恶性肿瘤已治愈，但这些个体出现严重迟发效应的风险增加，包括与年龄相关的并发症。免疫系统受损与老年人和儿童癌症幸存者出现这些情况有关，这可能是由于衰老免疫细胞表型伴有低度炎症，在老年人中这被称为“炎症衰老”。目前尚不清楚老年人和儿童癌症幸存者的这些观察结果是否由相似的机制所支撑。如果是这样，现有的关于免疫衰老表型和炎症衰老的知识可能会对儿童癌症幸存者有益。我们总结了关于儿童癌症幸存者和老年人免疫变化的最新研究结果，并强调了相似之处，同时确定了未来的研究方向。深入了解加速免疫衰老的潜在机制和免疫衰老标志物，可能有助于我们识别出出现严重健康并发症风险增加的个体。
