Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, United States.
Neurosci Lett. 2011 Jan 25;488(3):279-82. doi: 10.1016/j.neulet.2010.11.047. Epub 2010 Nov 23.
Many brain protective strategies have been tested over short survival intervals, but few have been examined for long term benefit. The inducible member of the Heat shock protein 70 (Hsp70) family, Heat shock protein 72 (Hsp72), has been widely found to reduce ischemic injury. Here we assessed outcome in Hsp72 transgenic overexpressing mice and wild type littermates for one month following transient focal ischemia. Hsp72 reduced infarct area lost and improved behavioral outcome on rotarod and foot fault at one month. Thus protection by Hsp72 overexpression is long lasting, and includes improved recovery of motor function over one month.
许多脑保护策略已经在短期生存时间内进行了测试，但很少有研究关注其长期益处。热休克蛋白 70（Hsp70）家族的诱导成员热休克蛋白 72（Hsp72）已被广泛发现可减轻缺血性损伤。在这里，我们评估了短暂局灶性缺血后一个月 Hsp72 过表达转基因小鼠和野生型同窝仔鼠的结果。Hsp72 减少了梗死面积的丧失，并改善了旋转棒和足部失误的行为结果在一个月。因此，Hsp72 的过表达具有持久的保护作用，包括在一个月以上的运动功能恢复。
