Department of Cardiology and Nephrology, 260th Hospital of the PLA, Shijiazhuang 050041, China.
Autoimmun Rev. 2011 Apr;10(6):299-304. doi: 10.1016/j.autrev.2010.11.004. Epub 2010 Nov 24.
Systemic lupus erythematosus (SLE) is an autoimmune disease characteristic of the immune complex-induced chronic inflammatory damages. The high-affinity pathogenic autoantibodies, which primarily originate from the self-reactive B cells underwent somatic hypermutation and class switch, principally but not exclusively, in germinal centers, contribute substantially to the inflammatory damages of multiple organs in SLE. Follicular helper T (T(FH)) cells constitute a distinct CD4+ T helper population beyond the Th1/Th2 paradigm. T(FH) cells can be critical for providing help to B cells allowing the formation of germinal center and the subsequent long-lived plasma cells differentiation. There is a growing body of evidence by far pointing toward the crucial roles of T(FH) cells in the overproduction of pathogenic autoantibodies and tissue damages in SLE. This article concerns the expansion and pathogenic mechanisms of T(FH) cells in SLE, and in particular, potential therapeutic implications for targeting T(FH) cells in this immunopathologically complicated disease.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，其特征为免疫复合物诱导的慢性炎症损伤。高亲和力的致病性自身抗体主要来源于经历体细胞超突变和类别转换的自身反应性 B 细胞，主要但并非完全在生发中心产生，对 SLE 中多个器官的炎症损伤有重要贡献。滤泡辅助 T（T（FH））细胞是超越 Th1/Th2 范式的一种独特的 CD4+T 辅助细胞群。T（FH）细胞对于向 B 细胞提供帮助以使生发中心形成和随后的长寿命浆细胞分化至关重要。迄今为止，越来越多的证据表明 T（FH）细胞在 SLE 中致病性自身抗体的过度产生和组织损伤中起关键作用。本文关注了 T（FH）细胞在 SLE 中的扩增和致病机制，特别是针对该免疫病理复杂疾病中的 T（FH）细胞的潜在治疗意义。
