Institute of Translational Medicine, University of Liverpool, UK.
Cell. 2010 Nov 24;143(5):682-5. doi: 10.1016/j.cell.2010.11.012.
Ubiquitin is a common demoninator in the targeting of substrates to all three major protein degradation pathways in mammalian cells: the proteasome, the lysosome, and the autophagosome. The factors that direct a substrate toward a particular route of degradation likely include ubiquitin chain length and linkage type, which may favor interaction with particular receptors or confer differential susceptibility to deubiquitinase activities associated with each pathway.
泛素是将底物靶向哺乳动物细胞中三种主要蛋白质降解途径（蛋白酶体、溶酶体和自噬体）的共同因素。指导底物朝向特定降解途径的因素可能包括泛素链长度和连接类型，这可能有利于与特定受体相互作用，或赋予与每种途径相关的去泛素酶活性的不同敏感性。
