放射治疗在皮肤黑色素瘤管理中的作用。

The role of radiation therapy in the management of cutaneous melanoma.

作者信息

Rao Nikhil G, Yu Hsiang-Hsuan M, Trotti Andrea, Sondak Vernon K

机构信息

Department of Radiation Oncology, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.

出版信息

Surg Oncol Clin N Am. 2011 Jan;20(1):115-31. doi: 10.1016/j.soc.2010.09.005.

DOI:10.1016/j.soc.2010.09.005

PMID:21111962

Abstract

Radiation therapy plays an integral role in the management of melanoma. Radiation therapy is infrequently needed for the treatment of the primary site, but there are occasions when it is appropriate. The role of adjuvant radiation therapy to resected nodal basins is becoming clearer from recent randomized data for patients at high risk. The role of radiotherapy combined with radiosensitizers, biologic or with hyperthermia, continues to evolve. Radiation therapy plays a vital role in the treatment of brain metastases and is useful for other systemic metastases. Emerging technology such as stereotactic radiation therapy may be useful in achieving durable palliation for selected patients.

摘要

放射治疗在黑色素瘤的治疗中起着不可或缺的作用。原发性病灶的治疗很少需要放射治疗，但在某些情况下是合适的。从最近针对高危患者的随机数据来看，辅助性放射治疗对切除的淋巴结区域的作用正变得更加清晰。放射治疗与放射增敏剂、生物制剂或热疗联合应用的作用仍在不断发展。放射治疗在脑转移瘤的治疗中起着至关重要的作用，对其他全身转移瘤也有用。立体定向放射治疗等新兴技术可能有助于为特定患者实现持久的姑息治疗。