慢性阻塞性肺疾病患者的晚期糖基化终产物及其受体（RAGE）增加。

Advanced glycation end products and its receptor (RAGE) are increased in patients with COPD.

机构信息

Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

出版信息

Respir Med. 2011 Mar;105(3):329-36. doi: 10.1016/j.rmed.2010.11.001. Epub 2010 Nov 26.

DOI:10.1016/j.rmed.2010.11.001

PMID:21112201

Abstract

UNLABELLED

Advanced Glycation End products (AGEs) are the products of nonenzymatic glycation and oxidation of proteins and lipids. Formation of AGEs is increased in response to hyperglycaemia, reactive oxygen species and ageing. AGEs are proinflammatory and can modify the extracellular matrix. RAGE (Receptor for Advanced Glycation End Products) mediates some of the effects of AGEs.

METHODS

Formalin-fixed lung tissue from patients who had lobectomy for bronchial carcinoma was used to investigate the presence of AGEs and RAGE. Subjects were divided into those with COPD and controls. Immunostaining for AGEs and RAGE was performed and the intensity of staining measured.

RESULTS

Subjects with COPD and controls were similar in age and smoking history but FEV(1)% predicted was lower for COPD than controls. Intensity of staining for AGEs was greater in the airways (p = 0.025) and alveolar walls (p = 0.004) in COPD. Intensity of staining for RAGE was also significantly increased in alveolar walls (p = 0.03) but not the airways. FEV(1)% predicted was correlated with the intensity of staining for AGEs in the airways and alveoli.

CONCLUSIONS

The increased staining for both AGEs and RAGE in COPD lung raises the possibility that the RAGE-AGEs interaction may have a role in the pathogenesis of COPD.

摘要

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高级糖基化终产物（AGEs）是蛋白质和脂质非酶糖化和氧化的产物。AGEs 的形成会因高血糖、活性氧和衰老而增加。AGEs 具有促炎作用，并能改变细胞外基质。RAGE（高级糖基化终产物受体）介导了 AGEs 的一些作用。

方法

使用因支气管癌行肺叶切除术患者的福尔马林固定肺组织来研究 AGEs 和 RAGE 的存在。受试者分为 COPD 组和对照组。进行 AGEs 和 RAGE 的免疫染色，并测量染色强度。

结果

COPD 组和对照组在年龄和吸烟史方面相似，但 COPD 组的 FEV1%预计值低于对照组。COPD 患者的气道（p = 0.025）和肺泡壁（p = 0.004）中 AGEs 染色强度更高。肺泡壁中 RAGE 的染色强度也明显增加（p = 0.03），但气道中没有。FEV1%预计值与气道和肺泡中 AGEs 的染色强度相关。