Gil Hyun-Il, Lim Sungwon, Kwon Min-Jung, Ham Soo-Youn, Lee Jonghoo, Song Jae-Uk
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, Republic of Korea.
Department of Nursing, Dongguk University-WISE, 123 Dongdae-ro, Gyeongju, Gyeongbuk, Republic of Korea.
BMC Pulm Med. 2025 Aug 9;25(1):383. doi: 10.1186/s12890-025-03869-6.
The triglyceride-glucose index (TyG) has emerged as a reliable proxy for insulin resistance and metabolic dysfunction, showing associations with various health outcomes. While the relationship between metabolic health and respiratory function has been established, the association between TyG and lung function remains unclear, particularly in Asian populations. Therefore, we investigated whether TyG is associated with decreased lung function in a large sample of healthy Koreans.
We analyzed data from 89,809 healthy Korean adults (46,739 men, mean age: 38.5 years) who underwent health examinations in 2019, stratifying participants into quartiles based on their TyG index. Lung function impairment was defined using the lower limit of normal (LLN) derived from spirometric values at the fifth percentile of our population. We calculated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for lung function impairment, using the lowest TyG quartile as the reference group.
Mean TyG index was 8.34 ± 0.57. Subjects in the highest TyG quartile exhibited the lowest predicted forced expiratory volume in one second (FEV1%) and forced vital capacity (FVC%) after adjusting for covariates (P < 0.001). Also, FEV1(L) /FVC(L) ratio significantly differ among the four quartiles (P < 0.001). Compared to the lowest quartile (Q1), the aORs with 95% CI for FEV1% below the LLN across increasing quartiles (Q2 to Q4) were 1.150 (1.002-1.320), 1.272 (1.103-1.466), and 1.535 (1.310-1.799), respectively. For FVC% below the LLN, aORs were 1.233 (1.065-1.428), 1.334 (1.159-1.536), and 1.745 (1.506-2.021), respectively. Both trends were statistically significant (all P for trend < 0.001). In contrast, the aORs for FEV1/FVC below the LLN showed no significant differences among groups (P for trend = 0.186).
We found a significant association between higher TyG index values and decreased lung function in a large sample of healthy Koreans. Longitudinal studies are needed to establish causality and explore the long-term implications of this relationship on respiratory health.
甘油三酯-葡萄糖指数（TyG）已成为胰岛素抵抗和代谢功能障碍的可靠指标，与多种健康结局相关。虽然代谢健康与呼吸功能之间的关系已得到证实，但TyG与肺功能之间的关联仍不明确，尤其是在亚洲人群中。因此，我们在大量健康韩国人中调查了TyG是否与肺功能下降有关。
我们分析了2019年接受健康检查的89809名健康韩国成年人（46739名男性，平均年龄：38.5岁）的数据，根据他们的TyG指数将参与者分为四分位数。肺功能损害是根据我们人群中第五百分位数的肺活量测定值得出的正常下限（LLN）来定义的。我们以最低TyG四分位数作为参照组，计算了肺功能损害的调整优势比（aOR）和95%置信区间（CI）。
平均TyG指数为8.34±0.57。在调整协变量后，TyG四分位数最高的受试者一秒用力呼气量预测值（FEV1%）和用力肺活量（FVC%）最低（P<0.001）。此外，四个四分位数之间的FEV1（L）/FVC（L）比值也存在显著差异（P<0.001）。与最低四分位数（Q1）相比，随着四分位数增加（Q2至Q4），FEV1%低于LLN的aOR（95%CI）分别为1.150（1.002-1.320）、1.272（1.103-1.466）和1.535（1.310-1.799）。对于FVC%低于LLN的情况，aOR分别为1.233（1.065-1.428）、1.334（1.159-1.536）和1.745（1.506-2.021）。两种趋势均具有统计学意义（所有趋势P<0.001）。相比之下，FEV1/FVC低于LLN的aOR在各组之间无显著差异（趋势P=0.186）。
我们在大量健康韩国人中发现，较高的TyG指数值与肺功能下降之间存在显著关联。需要进行纵向研究来确定因果关系，并探索这种关系对呼吸健康的长期影响。
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