Department of Human Anatomy and Physiology, Physiology Section, University of Padova, Via Marzolo, 3, 35100 Padova, Italy.
Respir Physiol Neurobiol. 2011 Feb 15;175(2):255-60. doi: 10.1016/j.resp.2010.11.012. Epub 2010 Nov 26.
The temperature dependence of airway smooth muscle cells and alveolar surfactant activity, and of the elastin stress-strain relationship, suggests that body warming may affect respiratory mechanics in vivo, a possibility that has not yet been investigated. To examine this hypothesis, healthy rats were studied using the end-inflation occlusion method under control conditions and after an infrared lamp was used for body warming. Hysteresis areas, the inspiratory work of breathing, and its elastic and resistive components were also calculated. After body warming, static and dynamic elastance, ohmic airway resistance, mean value of hysteresis, the inspiratory work of breathing, and additional resistance due to pendelluft and stress relaxation were all decreased. These data suggest that body warming reduces the inspiratory work of breathing by improving the elastic and resistive mechanical properties of airways. This effect is evident even for limited temperature variations suggesting that it may occur in the event of spontaneous pathological conditions, such as fever.
气道平滑肌细胞和肺泡表面活性剂活性以及弹性蛋白的应力-应变关系的温度依赖性表明，体温升高可能会影响体内的呼吸力学，而这一可能性尚未得到研究。为了检验这一假设，健康大鼠在对照条件下和使用红外灯进行身体加热后使用终末充气闭塞法进行了研究。还计算了滞后面积、吸气呼吸功以及其弹性和阻力成分。身体加热后，静态和动态弹性、欧姆气道阻力、滞后的平均值、吸气呼吸功以及 Pendelluft 和应力松弛引起的额外阻力均降低。这些数据表明，体温升高通过改善气道的弹性和阻力力学特性来降低吸气呼吸功。即使体温变化有限，这种效果也很明显，这表明它可能发生在自发病理情况下，如发热。
