Rubini A, Bondì M
Department of Human Anatomy and Physiology, Sect. Physiology, University od Padua Via Marzolo, Padova, Italy.
Acta Physiol (Oxf). 2007 Apr;189(4):379-83. doi: 10.1111/j.1748-1716.2007.01671.x.
To assess the effect of the oestral cycle on the respiratory mechanics of the rat.
We measured the main mechanical respiratory parameters, namely respiratory system and lung resistances and compliances, by the end-inflation occlusion method on two populations of female rats, during proestrous-oestrous and metaoestrous-diestrous phases.
Inflation-deflation loops of the lungs were found to be statistically higher in rats during metaoestrous-diestrous phase. No other statistically significant difference was found in the measured mechanical respiratory parameters.
Our results suggest that the naturally occurring fluctuations in serum sexual hormone levels during the sexual cycle influence the lung's hysteresis but do not influence the respiratory system and lung resistances or static compliances. A possible effect of female sexual hormones on surfactant activity is also suggested.
评估发情周期对大鼠呼吸力学的影响。
我们采用终末充气阻断法，对处于动情前期-发情期和间情期-动情后期的两组雌性大鼠，测量了主要的呼吸力学参数，即呼吸系统和肺的阻力及顺应性。
发现处于间情期-动情后期的大鼠肺的充气-放气环在统计学上更高。在所测量的呼吸力学参数中未发现其他统计学上的显著差异。
我们的结果表明，性周期中血清性激素水平的自然波动会影响肺的滞后现象，但不影响呼吸系统和肺的阻力或静态顺应性。还提示了雌性性激素对表面活性物质活性可能存在的影响。
