Department of Anatomy and Physiology, Section Physiology, University of Padova, Via Marzolo, 3, 35100 Padova, Italy.
Cytokine. 2010 Sep;51(3):266-73. doi: 10.1016/j.cyto.2010.06.015.
The end-inspiratory occlusion method was applied in anesthetized, paralyzed, positive pressure-ventilated rats to assess the possible effects of interleukin IL-6 on respiratory mechanics in normal rats. Measurements were made in control rats and in experimental animals before and after IL-6 intraperitoneal administration (15 ng/100 g), including static respiratory system elastance, the resistance to airflow and to the movement of respiratory system tissues, and the resistance due to lung stress-relaxation and mechanical inhomogeneity. Respiratory system hysteresis was also measured, and total mechanical breathing work rate and its elastic and resistive components calculated. Control rats did not exhibit alteration in respiratory mechanics during the observation period (30 min), while the experimental animals showed an increase in resistive pressure dissipations starting 15 min after IL-6 administration. Dose-dependent effects were also investigated. In a rather delayed effect, IL-6 increased the resistance to airflow and to the movement of respiratory system tissues, the resistance due to lung stress-relaxation and mechanical inhomogeneity, and the related resistive mechanical breathing work rate, and left the elastic pressure dissipation unaltered. The mechanisms by which IL-6 may contribute to the airways resistance increase which is seen in different respiratory diseases are likewise discussed.
吸气末阻断法应用于麻醉、去神经支配、正压通气的大鼠，以评估白细胞介素-6（IL-6）对正常大鼠呼吸力学的可能影响。在给予 IL-6 （15ng/100g）前后，测量了对照组大鼠和实验组大鼠的静态呼吸系统弹性、气流阻力和呼吸系统组织运动阻力、肺顺应性降低和机械异质性导致的阻力。还测量了呼吸系统滞后，计算了总机械呼吸功及其弹性和阻力分量。在观察期间（30 分钟），对照组大鼠的呼吸力学没有改变，而实验组大鼠在给予 IL-6 后 15 分钟开始出现阻力消散增加。还研究了剂量依赖性效应。在相当延迟的作用中，IL-6 增加了气流阻力和呼吸系统组织运动阻力、肺顺应性降低和机械异质性导致的阻力、相关的阻力机械呼吸功，而弹性压力消散保持不变。同样讨论了 IL-6 如何有助于不同呼吸疾病中观察到的气道阻力增加的机制。
