Toronto Rehabilitation Institute, Spinal Cord Rehabilitation Program, Toronto, Ontario, Canada.
Psychiatry Res. 2011 May 15;187(1-2):160-5. doi: 10.1016/j.psychres.2010.11.008. Epub 2010 Nov 27.
A substantial proportion of individuals with obsessive-compulsive disorder (OCD) do not endorse the dysfunctional beliefs proposed by cognitive models of OCD to be important in the onset and maintenance of symptoms. Previous research has attempted to characterize Low and High obsessive beliefs groups in terms of cognitive and symptom correlates to distil potential etiological differences in these subgroups of OCD patients. The current study sought to further examine potential neurocognitive differences between obsessive beliefs subgroups. Performance on the Wisconsin Card Sorting Test (WCST) was compared between a Low Beliefs OCD subgroup, a High Beliefs OCD subgroup, and two anxious control groups: Panic Disorder with Agoraphobia (PDA) and Social Phobia (SP). The High Beliefs OCD subgroup performed significantly poorer on WCST subscales compared to the other diagnostic groups. These findings were not accounted for by severity of OCD or depressive symptoms. The Low Beliefs OCD subgroup performed similar to the anxiety disorder control groups. The results suggest a potential interplay between heightened obsessive beliefs and neurocognitive inflexibility.
相当一部分强迫症（OCD）患者并不认同强迫症认知模型中提出的那些对症状的发生和维持很重要的功能失调信念。先前的研究试图根据认知和症状相关性来描述低和高强迫信念组，以提炼出这些 OCD 患者亚组中的潜在病因差异。本研究旨在进一步研究强迫信念亚组之间潜在的神经认知差异。威斯康星卡片分类测验（WCST）的表现被比较了低信念 OCD 亚组、高信念 OCD 亚组和两个焦虑对照组：广场恐怖症伴惊恐障碍（PDA）和社交恐惧症（SP）。与其他诊断组相比，高信念 OCD 亚组在 WCST 分量表上的表现明显更差。这些发现与 OCD 或抑郁症状的严重程度无关。低信念 OCD 亚组的表现与焦虑障碍对照组相似。结果表明，高度的强迫信念和神经认知灵活性之间可能存在相互作用。
