Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy.
Cereb Cortex. 2011 Jul;21(7):1574-92. doi: 10.1093/cercor/bhq218. Epub 2010 Nov 26.
Human posttraumatic epilepsy (PTE) is highly heterogeneous, ranging from mild remitting to progressive disabling forms. PTE results in simple partial, complex partial, and secondarily generalized seizures with a wide spectrum of durations and semiologies. PTE variability is thought to depend on the heterogeneity of head injury and patient's age, gender, and genetic background. To better understand the role of these factors, we investigated the seizures resulting from calibrated fluid percussion injury (FPI) to adolescent male Sprague-Dawley rats with video electrocorticography. We show that PTE incidence and the frequency and severity of chronic seizures depend on the location and severity of FPI. The frontal neocortex was more prone to epileptogenesis than the parietal and occipital, generating earlier, longer, and more frequent partial seizures. A prominent limbic focus developed in most animals, regardless of parameters of injury. Remarkably, even with carefully controlled injury parameters, including type, severity, and location, the duration of posttraumatic apnea and the age and gender of outbred rats, there was great subject-to-subject variability in frequency, duration, and rate of progression of seizures, indicating that other factors, likely the subjects' genetic background and physiological states, have critical roles in determining the characteristics of PTE.
人类创伤后癫痫（PTE）具有高度异质性，从轻度缓解到进行性致残形式不等。PTE 导致单纯部分性、复杂部分性和继发全面性发作，具有广泛的持续时间和临床表现。PTE 的变异性被认为取决于头部损伤的异质性以及患者的年龄、性别和遗传背景。为了更好地理解这些因素的作用，我们使用视频脑电图研究了经校准的液压冲击伤（FPI）对青春期雄性 Sprague-Dawley 大鼠引起的癫痫发作。我们发现，PTE 的发生率以及慢性癫痫发作的频率和严重程度取决于 FPI 的位置和严重程度。额皮质比顶叶和枕叶更容易发生癫痫发生，产生更早、更长和更频繁的部分性发作。大多数动物都形成了明显的边缘焦点，无论损伤参数如何。值得注意的是，即使严格控制损伤参数，包括损伤类型、严重程度和位置、创伤后呼吸暂停的持续时间以及杂交大鼠的年龄和性别，癫痫发作的频率、持续时间和进展率在个体之间仍存在很大的变异性，这表明其他因素，可能是受试动物的遗传背景和生理状态，在决定 PTE 的特征方面起着关键作用。
