Department of Social Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
J Med Ethics. 2010 Dec;36(12):810-5. doi: 10.1136/jme.2010.035444.
More than 25 years into the HIV epidemic, in excess of 2 million new infections continue to occur each year. HIV prevention research is crucial for groups at heightened risk for HIV, but the design and conduct of HIV prevention research with vulnerable populations worldwide raises considerable ethical challenges. The HIV Prevention Trials Network (HPTN) is a global collaborative network that conducts clinical and behavioural studies on non-vaccine interventions to reduce the transmission of HIV. In 2003, the HPTN developed ethical guidance to enhance the responsible conduct of its research activities and as a distinctive contribution to global research ethics. In what follows, the developments that motivated the drafting of a revised ethics document in 2009 are described, including the process by which that revision took place and some of the key differences between the HPTN ethics guidance and other relevant guidelines in the field.
超过 25 年的艾滋病毒流行，每年仍有超过 200 万例新感染。艾滋病毒预防研究对于艾滋病毒高危人群至关重要，但在全世界易受感染人群中进行艾滋病毒预防研究的设计和实施引起了相当大的伦理挑战。艾滋病毒预防试验网络（HPTN）是一个全球性合作网络，开展关于非疫苗干预措施的临床和行为研究，以减少艾滋病毒的传播。2003 年，HPTN 制定了伦理指导，以加强其研究活动的负责任进行，并作为对全球研究伦理的独特贡献。在下面的内容中，描述了促使 2009 年起草修订版伦理文件的发展情况，包括修订过程以及 HPTN 伦理指导与该领域其他相关准则之间的一些主要差异。
