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甲扁平苔藓：用依那西普成功治疗

Nail Lichen Planus: Successful Treatment with Etanercept.

作者信息

Irla N, Schneiter T, Haneke E, Yawalkar N

机构信息

Department of Dermatology, Bern University Hospital and University of Bern, Bern, Switzerland.

出版信息

Case Rep Dermatol. 2010 Oct 21;2(3):173-176. doi: 10.1159/000321419.

DOI:10.1159/000321419
PMID:21113341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2992401/
Abstract

BACKGROUND

Etanercept is a fully human tumor necrosis factor a receptor fusion protein that binds tumor necrosis factor a with greater affinity than natural receptors. Biologics are widely used in the treatment of psoriasis and psoriasis arthritis and may represent a new therapeutic option for some patients with psoriatic nail disease. CASE REPORT: We report a case of lichen planus limited to the toe nails successfully treated with etanercept monotherapy. CONCLUSION: The significant improvement of our case suggests that etanercept is an effective treatment modality for lichen planus limited particularly to the nails. Further controlled studies are needed to establish the effectiveness and therapeutic regimes.

摘要

背景

依那西普是一种全人源肿瘤坏死因子α受体融合蛋白，其与肿瘤坏死因子α的结合亲和力高于天然受体。生物制剂广泛应用于银屑病和银屑病关节炎的治疗，对于一些银屑病甲病患者可能是一种新的治疗选择。病例报告：我们报告1例仅累及趾甲的扁平苔藓患者，采用依那西普单药治疗取得成功。结论：我们的病例显著改善表明，依那西普是治疗尤其局限于指甲的扁平苔藓的一种有效治疗方式。需要进一步的对照研究来确定其有效性和治疗方案。

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本文引用的文献

1
Evaluation of the efficacy and safety of infliximab on psoriatic nails: an unblinded, nonrandomized, open-label study.英夫利昔单抗治疗银屑病甲的疗效和安全性评估：一项非盲、非随机、开放标签研究。
Br J Dermatol. 2008 Aug;159(2):453-6. doi: 10.1111/j.1365-2133.2008.08686.x. Epub 2008 Jun 28.
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Rapid response of nail psoriasis to etanercept.指甲银屑病对依那西普的快速反应。
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3
Baseline nail disease in patients with moderate to severe psoriasis and response to treatment with infliximab during 1 year.中度至重度银屑病患者的基线指甲疾病及英夫利昔单抗治疗1年的反应
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4
Lichen planus associated with etanercept.与依那西普相关的扁平苔藓。
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Type I interferon-associated cytotoxic inflammation in lichen planus.扁平苔藓中与I型干扰素相关的细胞毒性炎症
J Cutan Pathol. 2006 Oct;33(10):672-8. doi: 10.1111/j.1600-0560.2006.00527.x.
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Oral erosive lichen planus treated with efalizumab.依法利珠单抗治疗口腔糜烂性扁平苔藓。
Arch Dermatol. 2006 Jun;142(6):680-2. doi: 10.1001/archderm.142.6.680.
8
Treatment of generalized lichen planus with alefacept.用阿法西普治疗泛发性扁平苔藓。
Arch Dermatol. 2006 Feb;142(2):151-2. doi: 10.1001/archderm.142.2.151.
9
The nails in lichen planus.
Br J Dermatol. 1961 Jul;73:288-92. doi: 10.1111/j.1365-2133.1961.tb14448.x.