Battaglini Claudio L
Department of Exercise and Sport Science and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 25 C Fetzer Hall, Chapel Hill, North Carolina 27599-8700, USA.
Recent Results Cancer Res. 2011;186:275-304. doi: 10.1007/978-3-642-04231-7_12.
As previously presented in other chapters of this book, exercise has been shown through large scale studies to be associated with significant improvements in physical and psychological parameters in patients with one of several different tumor types (Galvao et al. 2010; Schwartz and Winters-Stone 2009; Galvao et al. 2009; Segal et al. 2009; Courneya et al. 2008a, b; Ligibel et al. 2008; Courneya et al. 2007; Schmitz et al. 2005a; Fairey et al. 2005). In addition, well conducted systematic reviews of the literature that have explored the effects of exercise before, during, or after anticancer therapy have consistently shown positive outcomes to patients treated for solid tumors. Consistent findings include an overall reduction in fatigue, depression, anxiety, and distress, paired with positive changes in fitness parameters such as aerobic capacity and overall muscle function (Speck et al. 2010; Jones et al. 2006; McNeely et al. 2006; Markes et al. 2006; Schmitz et al. 2005; Galvao and Newton 2005). However, a relative paucity of data exists in the area of exercise interventions for adult patients with hematological malignancies. This chapter reviews the current literature regarding the administration of exercise in adult patients diagnosed with hematological cancer. The few exercise intervention studies conducted in patients with hematological cancers suggest that it is feasible to administer exercise to most patients and that exercise should be considered as an intervention to alleviate treatment-related symptoms. Yet, efficacy along with the appropriate mode, intensity, and frequency of exercise training in different types of hematological cancers are yet to be established and require further research.
正如本书其他章节中之前所介绍的，通过大规模研究表明，运动与几种不同肿瘤类型之一的患者的身体和心理参数的显著改善相关（Galvao等人，2010年；Schwartz和Winters-Stone，2009年；Galvao等人，2009年；Segal等人，2009年；Courneya等人，2008a、b；Ligibel等人，2008年；Courneya等人，2007年；Schmitz等人，2005a；Fairey等人，2005年）。此外，对探索抗癌治疗前、治疗期间或治疗后运动效果的文献进行的精心系统综述一直表明，对实体瘤患者进行治疗会产生积极结果。一致的发现包括疲劳、抑郁、焦虑和痛苦总体减轻，同时体能参数如有氧运动能力和整体肌肉功能出现积极变化（Speck等人，2010年；Jones等人，2006年；McNeely等人，2006年；Markes等人，2006年；Schmitz等人，2005年；Galvao和Newton，2005年）。然而，在成年血液系统恶性肿瘤患者的运动干预领域，数据相对较少。本章回顾了有关对诊断为血液系统癌症的成年患者进行运动管理的当前文献。在血液系统癌症患者中进行的少数运动干预研究表明，对大多数患者进行运动管理是可行的，并且运动应被视为缓解治疗相关症状的一种干预措施。然而，不同类型血液系统癌症中运动训练的效果以及适当的运动方式、强度和频率尚未确定，需要进一步研究。
