Story Christina, Bryant Ashley Leak, Phillips Brett, Bailey Charlotte, Shields Edgar W, Battaglini Claudio
Department of Exercise and Sport Science, The University of North Carolina at Chapel Hill, NC, USA.
School of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Biol Res Nurs. 2016 Jul;18(4):432-8. doi: 10.1177/1099800416633836. Epub 2016 Mar 1.
Cardiopulmonary exercise testing (CPET), the gold standard of cardiopulmonary evaluation, is used to determine VO2 levels at different aerobic exercise training intensities; however, it may not be feasible to conduct CPET in all clinical settings.
To compare the heart rate reserve (HRR) and percent of 220-age methods for prescribing cycle ergometry exercise intensity using heart rate (HR) against the HRs obtained during a CPET in adults undergoing treatment for acute leukemia (AL).
In this exploratory study, part of a larger randomized controlled trial, 14 adults with AL completed CPET on a cycle ergometer with indirect calorimetry within 96 hr of admission to a cancer hospital to determine VO2peak and HR corresponding to low (40% VO2peak), moderate (60% VO2peak), and high (75% VO2peak) exercise intensities. Analyses of variance were used to compare estimated HR for each intensity level using the HRR and percent of 220-age methods with HR determined via VO2peak.
HR corresponding to low-intensity exercise differed significantly across all three methods (p ≤ .05). No significant differences were observed between HR estimated via the percent of 220-age method and determined via VO2peak at moderate (100 ± 8 and 113 ± 24 bpm, p = .122) or high intensities (125 ± 10 and 123 ± 25 bpm, p = .994).
In adults with AL, HR-based methods for defining aerobic exercise intensities should be used with caution. At low intensity, neither should be used, while at moderate and high intensities, the percent of 220-age equation might serve as an adequate substitute for CPET.
心肺运动试验（CPET）是心肺评估的金标准，用于确定不同有氧运动训练强度下的摄氧量水平；然而，在所有临床环境中进行CPET可能并不可行。
比较心率储备（HRR）和220-年龄百分比法在为接受急性白血病（AL）治疗的成人进行自行车测力计运动强度处方时，根据心率（HR）与CPET期间获得的心率的差异。
在这项探索性研究中，作为一项更大的随机对照试验的一部分，14名患有AL的成年人在入住癌症医院96小时内，在带有间接测热法的自行车测力计上完成了CPET，以确定对应于低（40%摄氧量峰值）、中（60%摄氧量峰值）和高（75%摄氧量峰值）运动强度的摄氧量峰值和心率。方差分析用于比较使用HRR和220-年龄百分比法对每个强度水平估计的心率与通过摄氧量峰值确定的心率。
三种方法中，低强度运动对应的心率差异显著（p≤0.05）。在中等强度（100±8和113±24次/分钟，p = 0.122）或高强度（125±10和123±25次/分钟，p = 0.994）时，通过220-年龄百分比法估计的心率与通过摄氧量峰值确定的心率之间未观察到显著差异。
在患有AL的成年人中，应谨慎使用基于心率的方法来定义有氧运动强度。在低强度时，两种方法都不应使用，而在中等强度和高强度时，220-年龄公式百分比可能足以替代CPET。
