心脏移植后急性细胞排斥反应患者中 Th1、Th17 和 FoxP3+T 细胞的动态变化。
Dynamic changes in Th1, Th17, and FoxP3+ T cells in patients with acute cellular rejection after cardiac transplantation.
机构信息
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Clin Transplant. 2011 Mar-Apr;25(2):E177-86. doi: 10.1111/j.1399-0012.2010.01362.x. Epub 2010 Nov 28.
Previously, studies suggest that CD4(+) effector T-cell subsets participate in allograft rejection. However, the dynamic changes and relative roles of these CD4(+) effector T-cell subsets, especially Th17 cells, have not been systemically examined in patients with acute rejection after cardiac transplantation. In this study, we have studied and compared these CD4(+) T-cell subsets in peripheral blood and endomyocardial biopsies (EMB) in patients with stable-graft and acute cellular rejection. We observed that the gene expressions including T-bet, IFN-γ, RORγt, IL-17, IL-23, and FoxP3, the functional marker of Th1, Th17, and FoxP3(+) CD4(+) T cells, were elevated in EMB samples from patients with acute graft rejection. Accordingly, the percentages of circulating Th1, Th17, and FoxP3(+) CD4(+) T cells were also significantly increased. The data suggest that Th1, Th17, and FoxP3(+) CD4(+) T cells are associated with acute graft rejection in patients with cardiac transplantation.
先前的研究表明，CD4(+)效应 T 细胞亚群参与同种异体移植物排斥反应。然而，在心脏移植后发生急性排斥反应的患者中，这些 CD4(+)效应 T 细胞亚群（尤其是 Th17 细胞）的动态变化及其相对作用尚未得到系统研究。在这项研究中，我们研究并比较了稳定移植物和急性细胞性排斥反应患者的外周血和心肌活检（EMB）中的这些 CD4(+)T 细胞亚群。我们观察到，急性移植物排斥反应患者的 EMB 样本中，包括 T-bet、IFN-γ、RORγt、IL-17、IL-23 和 FoxP3（Th1、Th17 和 FoxP3(+)CD4(+)T 细胞的功能标志物）的基因表达升高。相应地，循环 Th1、Th17 和 FoxP3(+)CD4(+)T 细胞的百分比也显著增加。数据表明，Th1、Th17 和 FoxP3(+)CD4(+)T 细胞与心脏移植患者的急性移植物排斥反应有关。
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