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肝与血管化腹直肌后鞘筋膜复合组织同种异体移植。

Liver and vascularized posterior rectus sheath fascia composite tissue allotransplantation.

机构信息

Section of Plastic and Reconstructive Surgery, University of Chicago, Chicago, IL, USA.

出版信息

Am J Transplant. 2010 Dec;10(12):2712-6. doi: 10.1111/j.1600-6143.2010.03331.x.

Abstract

Abdominal wall closure in pediatric solid organ recipients may be confounded by donor size discrepancy and structural insults from previous surgery. Here we describe the novel use of vascularized donor abdominal wall posterior rectus sheath fascia, as a composite tissue allotransplant (CTA), to achieve abdominal wall closure in a liver and double kidney pediatric recipient who could not be closed primarily due to donor/recipient size mismatch. The posterior rectus sheath fascia was procured in continuity with the liver and falciform ligament. Blood supply was achieved using the single hepatic artery anastomosis as part of the standard liver transplantation procedure. Specimens of posterior rectus sheath fascia taken on postoperative days 3 and 30 showed no signs of acute rejection. The patient succumbed to an overwhelming fungal infection on day 51, with no signs of intraabdominal involvement. The patient received no additional immunosuppression in conjunction with the posterior rectus sheath fascia allotransplant.

摘要

在小儿实体器官受者中,由于供体大小差异和先前手术的结构损伤,腹壁关闭可能会变得复杂。在这里,我们描述了一种新的方法,即使用血管化的供体腹壁后直肌鞘筋膜作为复合组织同种异体移植(CTA),以实现一名因供体/受体大小不匹配而无法直接关闭腹壁的肝和双肾小儿受者的腹壁关闭。后直肌鞘筋膜与肝和镰状韧带连续采集。通过使用单个肝动脉吻合术作为标准肝移植手术的一部分来实现血液供应。术后第 3 天和第 30 天采集的后直肌鞘筋膜标本未见急性排斥反应迹象。患者在第 51 天死于真菌性感染,无腹腔内受累迹象。该患者在接受后直肌鞘筋膜同种异体移植时未接受额外的免疫抑制治疗。

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