Hellgren L, Vincent J
J Int Med Res. 1977;5(5):334-7. doi: 10.1177/030006057700500508.
Necrotic materials most frequently found in leg ulcers, including crusts with fibrinogen, pus and blood clots, were exposed to solutions of streptokinase-streptodornase and stabilized crystalline trypsin respectively. The investigations were performed at the temperatures of 26 degrees and 33 degrees C, representing the extreme values of the temperature range found in leg ulcers (arteriosclerotic ulcers, stasis ulcers) and at the pH corresponding to that of the enzyme preparations in wet dressings. Streptokinase-streptodornase demonstrated in vitro a more potent proteolytic activity than crystalline trypsin on necroses, crusts of fibrinoid and purulent exudate, which were more rapidly and thoroughly broken up. Both enzyme preparations were, however, equally effective on three-day-old blood clots.
在腿部溃疡中最常见的坏死物质，包括含有纤维蛋白原的痂皮、脓液和血凝块，分别暴露于链激酶 - 链道酶溶液和稳定化结晶胰蛋白酶溶液中。研究在26摄氏度和33摄氏度的温度下进行，这两个温度代表了腿部溃疡（动脉硬化性溃疡、淤积性溃疡）中发现的温度范围的极值，且pH值与湿敷敷料中酶制剂的pH值相对应。在体外，链激酶 - 链道酶对坏死组织、类纤维蛋白痂皮和脓性渗出物的蛋白水解活性比结晶胰蛋白酶更强，这些物质能更快、更彻底地被分解。然而，两种酶制剂对三天龄的血凝块效果相同。
