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在菲律宾实施乙型肝炎母婴阻断国家政策:改善实施的经验教训。

Implementing a national policy for hepatitis B birth dose vaccination in Philippines: lessons for improved delivery.

机构信息

World Health Organization - Philippines Country Office, Manila, Philippines.

出版信息

Vaccine. 2011 Jan 29;29(5):941-5. doi: 10.1016/j.vaccine.2010.11.047. Epub 2010 Nov 27.

Abstract

BACKGROUND

An estimated seven million Filipinos (10-12% of the population) are chronically infected with hepatitis B virus (HBV). Achieving high birth dose coverage with hepatitis B vaccine is critical for achieving the World Health Organization's Western Pacific Regional goal of reducing the prevalence of chronic HBV among children 5 years of age to <2% by 2012.

METHODS

Seven months after the Philippines adopted a hepatitis B vaccine birth dose policy, hospitals with the highest number of deliveries were invited to participate in an assessment of implementation of the birth dose policy. Additionally, in metro Manila birth dose coverage was estimated before and after conducting a training workshop and supervisory follow-up for practitioners conducting home deliveries or deliveries at lying-in clinics.

RESULTS

Of the country's largest 150 hospitals in terms of authorized bed capacity, 85 (56%) were included in this assessment. These hospitals had 55,719 deliveries during July-September 2007. Of these, 54% infants had a documented birth dose; however, only 22% were vaccinated within 24h of delivery. Having a copy of the hepatitis B vaccine vaccination policy (prevalence odds ratio [pOR]=4.7, 95% confidence interval [CI]=1.2-18.0), having standing orders pOR=4.8, 95% CI=1.3-18.1 and providing training pOR=18.9, 95% CI=5.3-67.0 were associated with >50% birth dose coverage in a hospital. In metro-Manila, regardless of place of birth, the training workshop and supervisory follow-up significantly improved hepatitis B vaccine administration within 24h after birth, increasing from 19% before to 74% after the training workshop and follow-up.

CONCLUSIONS

Experience in the Philippines showed that actions by national, regional and health facility policy makers such as establishing national policies, distributing detailed and specific guidelines, conducting effective training and supervision, and having hospital standing orders substantially increased hepatitis B vaccine birth dose coverage.

摘要

背景

据估计,有 700 万菲律宾人(占总人口的 10-12%)患有慢性乙型肝炎病毒(HBV)感染。通过乙型肝炎疫苗实现高出生剂量覆盖率对于实现世界卫生组织西太平洋区域目标至关重要,该目标是到 2012 年将 5 岁以下儿童慢性 HBV 流行率降低至<2%。

方法

在菲律宾采用乙型肝炎疫苗出生剂量政策 7 个月后,邀请拥有最多分娩量的医院参与对出生剂量政策实施情况的评估。此外,在马尼拉大都会地区,在对进行家庭分娩或产褥诊所分娩的从业者进行培训研讨会和监督随访之前和之后,对出生剂量覆盖率进行了估计。

结果

在授权床位容量方面,该国最大的 150 家医院中有 85 家(56%)参与了这项评估。这些医院在 2007 年 7 月至 9 月期间有 55719 例分娩。其中,54%的婴儿有记录的出生剂量;然而,只有 22%的婴儿在分娩后 24 小时内接种疫苗。拥有乙型肝炎疫苗接种政策副本(流行率优势比 [pOR]=4.7,95%置信区间 [CI]=1.2-18.0)、有标准医嘱(pOR=4.8,95%CI=1.3-18.1)和提供培训(pOR=18.9,95%CI=5.3-67.0)与医院 50%以上的出生剂量覆盖率相关。在马尼拉大都会地区,无论出生地点如何,培训研讨会和监督随访显著提高了出生后 24 小时内乙型肝炎疫苗的接种率,从培训研讨会和随访前的 19%增加到 74%。

结论

菲律宾的经验表明,国家、地区和卫生机构政策制定者采取行动,如制定国家政策、分发详细和具体的指南、进行有效培训和监督,并制定医院标准医嘱,可大大提高乙型肝炎疫苗出生剂量覆盖率。

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