CpG 寡脱氧核苷酸可预防小鼠模型中的 2009 年 H1N1 大流行性流感病毒感染。
CpG oligodeoxynucleotides protect against the 2009 H1N1 pandemic influenza virus infection in a murine model.
机构信息
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
出版信息
Antiviral Res. 2011 Jan;89(1):124-6. doi: 10.1016/j.antiviral.2010.11.013. Epub 2010 Nov 27.
The 2009 H1N1 influenza virus pandemic poses a global public health threat, and there is a critical need for antiviral drugs for pandemic control. CpG oligodeoxynucleotides have strong immunostimulatory properties and are expected to be used as prophylactic agents to protect against microbial infections. The present study evaluated the efficacy of synthetic CpG oligodeoxynucleotide (ODN) 1826 against pandemic H1N1 virus infection in a murine model. A single injection of 15 μg ODN 1826 intraperitoneally prior to virus challenge inhibits virus replication in lungs, reduces lung lesions and prevents mortality in mice, indicating CpG ODNs as a possible strategy for future influenza pandemics control.
2009 年 H1N1 流感病毒大流行对全球公共卫生构成威胁，因此迫切需要抗病毒药物来进行大流行控制。CpG 寡脱氧核苷酸具有强大的免疫刺激特性，有望被用作预防药物来预防微生物感染。本研究评估了合成 CpG 寡脱氧核苷酸（ODN）1826 在小鼠模型中对大流行 H1N1 病毒感染的疗效。在病毒攻击前通过腹腔内注射 15μg ODN 1826 可抑制肺部病毒复制，减少肺部病变并预防小鼠死亡，这表明 CpG ODN 是未来流感大流行控制的一种可能策略。
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