外源性人ω干扰素抑制大流行 2009 年 A（H1N1）流感病毒的抗病毒潜力。
Antiviral potential of exogenous human omega interferon to inhibit pandemic 2009 A (H1N1) influenza virus.
机构信息
State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
出版信息
Viral Immunol. 2011 Oct;24(5):369-74. doi: 10.1089/vim.2011.0003.
The pandemic 2009 H1N1 influenza virus broke out in North America and spread rapidly throughout the world. The type I interferon (IFN) response represents one of the first lines of defense against influenza virus infections. In this study, the protective potential of human exogenous IFN-ω against pandemic 2009 A (H1N1) influenza virus was assessed both in vitro and in guinea pigs. The viral loads of pandemic 2009 A (H1N1) influenza virus strains A/California/04/2009 and A/Beijing/501/2009 were reduced by up to 5000-fold in Caco-2 cells by the addition of human IFN-ω. With daily intranasal treatment with human IFN-ω the viral load of pandemic 2009 A (H1N1) influenza virus strain A/California/04/2009 decreased by 1000-fold in lung tissues of guinea pigs. These results provide strong support for the application of human IFN-ω pretreatment to human influenza control.
2009 年甲型 H1N1 流感大流行病毒在北美爆发，并迅速在全球传播。Ⅰ型干扰素（IFN）应答代表了针对流感病毒感染的第一道防线之一。在这项研究中，人类外源性 IFN-ω 对大流行 2009 年 A （H1N1）流感病毒的保护潜力在体外和豚鼠中进行了评估。通过添加人 IFN-ω，大流行 2009 年 A （H1N1）流感病毒株 A/California/04/2009 和 A/Beijing/501/2009 的病毒载量在 Caco-2 细胞中减少了多达 5000 倍。通过每日鼻内给予人 IFN-ω，大流行 2009 年 A （H1N1）流感病毒株 A/California/04/2009 在豚鼠肺组织中的病毒载量减少了 1000 倍。这些结果为应用人 IFN-ω 预处理进行人类流感控制提供了有力支持。
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