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[牛奶蛋白过敏的饮食治疗]

[Dietetic treatment of cow's milk protein allergy].

作者信息

Dupont C, Chouraqui J-P, de Boissieu D, Bocquet A, Bresson J-L, Briend A, Darmaun D, Frelut M-L, Ghisolfi J, Girardet J-P, Goulet O, Hankard R, Rieu D, Rigo J, Vidailhet M, Turck D

机构信息

Hôpital Saint-Vincent-de-Paul, université Paris Descartes, 82 avenue Denfert-Rochereau, Paris cedex 14, France.

出版信息

Arch Pediatr. 2011 Jan;18(1):79-94. doi: 10.1016/j.arcped.2010.08.029. Epub 2010 Nov 5.

Abstract

New data on food allergy has recently changed the management of children with cow's milk protein allergy (CMPA). The diagnosis of CMPA first requires the elimination of cow's milk proteins and then an oral provocation test following a standard diagnostic procedure for food allergy, without which the elimination diet is unjustified and sometimes harmful. Once the diagnosis is made, the elimination diet is strict, at least until the age of 9-12 months. If the child is not breastfed or the mother cannot or no longer wishes to breastfeed, the first choice is a formula based on extensive hydrolyzate of cow's milk (eHF), provided that its effectiveness has been demonstrated. When eHF fails, a formula based on amino acids is warranted. eHF based on rice protein hydrolysates is an alternative to cow's milk eHF. Infant formulas based on soy protein can be used after the age of 6 months, after verification of good clinical tolerance to soy. Most commonly, CMPA disappears within 2 or 3 years of life. However, the age of recovery varies depending on the child and the type of CMPA, and whether or not it is IgE-mediated, the first being more sustainable. When the child grows, a hospital oral provocation test evaluates the development of tolerance and, if possible, authorizes continuing the reintroduction of milk proteins at home. Some children with CMPA will tolerate only a limited daily amount of cow's milk proteins. The current therapeutic options are designed to accelerate the acquisition of tolerance, which seems facilitated by regular exposure to cow's milk proteins.

摘要

最近,食物过敏的新数据改变了对牛奶蛋白过敏(CMPA)儿童的管理方法。CMPA的诊断首先需要消除牛奶蛋白,然后按照食物过敏的标准诊断程序进行口服激发试验,否则消除饮食是不合理的,有时甚至是有害的。一旦确诊,消除饮食必须严格执行,至少持续到9至12个月大。如果孩子没有进行母乳喂养,或者母亲不能或不再愿意母乳喂养,首选是基于深度水解牛奶(eHF)的配方奶粉,前提是其有效性已得到证实。当eHF无效时,则需要使用氨基酸配方奶粉。基于大米蛋白水解物的eHF是牛奶eHF的替代品。基于大豆蛋白的婴儿配方奶粉可以在6个月大以后使用,前提是已证实对大豆具有良好的临床耐受性。最常见的情况是,CMPA在儿童2至3岁时消失。然而,恢复的年龄因孩子、CMPA的类型以及是否由IgE介导而有所不同,前者更具可持续性。当孩子长大后,医院的口服激发试验会评估耐受性的发展情况,并在可能的情况下允许在家中继续重新引入牛奶蛋白。一些患有CMPA的儿童只能耐受有限的每日牛奶蛋白摄入量。目前的治疗选择旨在加速耐受性的获得,定期接触牛奶蛋白似乎有助于实现这一点。

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