Specialist Registrar in Clinical Chemistry and Metabolic Medicine, Department of Clinical Biochemistry and Molecular Genetics, Russells Hall Hospital, Dudley, West Midlands, UK.
Int J Clin Pract. 2010 Dec;64(13):1793-5. doi: 10.1111/j.1742-1241.2010.02383.x.
Impaired fasting glycaemia (IFG) is an indication for oral glucose tolerance test (OGTT). World health organisation and International Diabetes Federation define IFG as fasting plasma glucose (FPG) levels of 6.1–6.9 mmol/l. However, American Diabetes Association still recommends a range of 5.6–6.9 mmol/l as IFG.We performed an audit to assess the outcome of OGTT at various cut offs of FPG levels in patients at high risk of developing diabetes.
Laboratory dataon OGTT performed over a period of 1 year in a district general hospital were collected. Patients with FPG levels between 5.6 and 6.9 mmol/l were selected and the outcome was analysed.
Our audit shows that in patients with FPG levels of 5.6–6.0 mmol/l, 19% had diabetes and 43% had impaired glucose tolerance (IGT).
The percentage of subjects with abnormal OGTT in our study is much higher than that of Decode study [Diabetologica, 42 (1999) 647] (7% diabetes and 29% IGT). However, Decode study had included general population whereas our data were collected from subjects who are at high risk of developing diabetes. We conclude that in these subjects the lower cut off level of 5.6 mmol/l for FPG should be used as an indication for OGTT.
空腹血糖受损（IFG）是口服葡萄糖耐量试验（OGTT）的指征。世界卫生组织和国际糖尿病联合会将 IFG 定义为空腹血浆葡萄糖（FPG）水平为 6.1-6.9mmol/L。然而，美国糖尿病协会仍建议将 5.6-6.9mmol/L 的范围作为 IFG。我们进行了一项审计，以评估在高糖尿病风险患者中，各种 FPG 水平截断值下 OGTT 的结果。
在一家地区综合医院，收集了在 1 年内进行的 OGTT 的实验室数据。选择 FPG 水平在 5.6-6.9mmol/L 之间的患者，并对结果进行分析。
我们的审计显示，在 FPG 水平为 5.6-6.0mmol/L 的患者中，19%患有糖尿病，43%患有糖耐量受损（IGT）。
与 Decode 研究[Diabetologia，42（1999）647]（7%糖尿病和 29%IGT）相比，我们研究中异常 OGTT 的受试者比例要高得多。然而，Decode 研究纳入了普通人群，而我们的数据是从有发展为糖尿病高风险的受试者中收集的。我们的结论是，在这些受试者中，FPG 的较低截断值 5.6mmol/L 应作为 OGTT 的指征。
