Colella Giuseppe, Tozzi Umberto, Pagliarulo Valentina, Bove Pierfrancesco
Department of Oral and Maxillo-Facial Surgery, Piazza Miraglia SUN, Naples, Italy.
J Craniofac Surg. 2010 Nov;21(6):1978-81. doi: 10.1097/SCS.0b013e3181f50406.
Warthin tumor, also known as papillary cystadenoma lymphomatosum, is a fairly common tumor. It makes up 14% to 30% of parotid tumors. There has been much interest in this tumor because of its typical and intriguing morphologic features: the association of benign-looking lymphoid and epithelial components and its frequent occurrence in the intraparotid or periparotid lymph nodes. Moreover, multifocal and/or bilateral Warthin tumors have been reported, and malignant transformation of Warthin tumor and its association with other malignancies have been documented. Warthin tumor can sometimes be confused with other pathologic lesions because of symptoms and signs that accompany the disease, so it could be treated as other pathologic lesions.
We present 3 patients. The first one had a differentiated squamous cell carcinoma, no lymph node metastasis, and a Warthin tumor of the left parotid gland. The other 2 patients presented monoclonal gammopathy and a high tracer uptake in the left parotid gland by the 18F-fluorodeoxyglucose positron emission tomography/computed tomography total body.
The aim of this study was to evaluate the clinical and histopathologic features of 3 cases where clinical presentation of a Warthin tumor lies in the possible errors in diagnosis and decision making and not least in the management of the patient.
沃辛瘤，又称乳头状囊腺瘤淋巴瘤，是一种较为常见的肿瘤。它占腮腺肿瘤的14%至30%。由于其典型且引人入胜的形态学特征，即看似良性的淋巴样和上皮成分的组合以及其在腮腺内或腮腺周围淋巴结中的频繁发生，人们对这种肿瘤一直很感兴趣。此外，多灶性和/或双侧沃辛瘤已有报道，并且沃辛瘤的恶性转化及其与其他恶性肿瘤的关联也有文献记载。沃辛瘤有时会因其伴随疾病的症状和体征而与其他病理病变混淆，因此可能会被当作其他病理病变进行治疗。
我们介绍3例患者。第一例患有分化型鳞状细胞癌，无淋巴结转移，且左侧腮腺有一个沃辛瘤。另外2例患者表现为单克隆丙种球蛋白病，通过18F - 氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描全身检查发现左侧腮腺有高示踪剂摄取。
本研究的目的是评估3例沃辛瘤患者的临床和组织病理学特征，这些病例中沃辛瘤的临床表现可能导致诊断和决策失误，尤其是在患者管理方面。
