Bottini Davide J, Gentile Pietro, Ascenzi Paola, Galante Vincenzo, Ricci Antonio, Cervelli Valerio
Department of Plastic and Reconstructive Surgery, Policlinico Casilino University of Rome Tor Vergata, Rome, Italy.
J Craniofac Surg. 2010 Nov;21(6):1994-6. doi: 10.1097/SCS.0b013e3181f50524.
The epithelioid hemangioendothelioma is an uncommon vascular neoplasm. Numerous sites of involvement are possible, but these tumors most commonly arise in the soft tissues, liver, and lung. We report a case of epithelioid hemangioendothelioma presenting as a single lesion on the nasal portion of the maxilla. Histologically, the tumor within bone and skin exhibited cords and nests of plump, epithelioid-appearing cells exhibiting rudimentary vascular differentiation within a myxohyaline stroma. Immunohistochemical reactivities for factor VIII-related antigen, CD31, CD34, and vimentin were demonstrated. Wide local excision with close clinical follow-up seems to be the treatment of choice for these tumors.
上皮样血管内皮瘤是一种罕见的血管肿瘤。其可能累及多个部位，但这些肿瘤最常发生于软组织、肝脏和肺。我们报告一例上皮样血管内皮瘤，表现为上颌骨鼻部的单个病灶。组织学上，骨和皮肤内的肿瘤呈现出条索状和巢状的丰满上皮样细胞，在黏液透明基质内表现出初步的血管分化。免疫组化显示因子VIII相关抗原、CD31、CD34和波形蛋白呈阳性反应。广泛局部切除并密切临床随访似乎是这些肿瘤的首选治疗方法。
