Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
J Antibiot (Tokyo). 2011 Feb;64(2):193-6. doi: 10.1038/ja.2010.154. Epub 2010 Dec 1.
Three new sterigmatocystin derivatives, oxisterigmatocystin A (1), oxisterigmatocystin B (2) and oxisterigmatocystin C (3), together with one known compound, 5-methoxysterigmatocystin (4), were isolated from the deep-sea-derived fungus Aspergillus versicolor. The structures of the new compounds were elucidated by spectroscopic methods. The cytotoxicities of compounds 1-4 were evaluated against the A-549 and HL-60 cell lines. Compound 4 exhibited moderate cytotoxicities against the A-549 and HL-60 cell lines with IC(50) value of 3.86 and 5.32 μM, respectively.
从深海来源的青霉 Aspergillus versicolor 中分离得到三个新的杂色曲菌素衍生物，即氧杂色曲菌素 A（1）、氧杂色曲菌素 B（2）和氧杂色曲菌素 C（3），以及一个已知化合物 5-甲氧基杂色曲菌素（4）。通过光谱方法阐明了新化合物的结构。评估了化合物 1-4 对 A-549 和 HL-60 细胞系的细胞毒性。化合物 4 对 A-549 和 HL-60 细胞系表现出中等的细胞毒性，IC50 值分别为 3.86 和 5.32 μM。
