台中支顶孢菌素 A 至 H 的结构鉴定

Prenylated Polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07.

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.

出版信息

J Nat Prod. 2011 May 27;74(5):1106-10. doi: 10.1021/np2000478. Epub 2011 Apr 12.

DOI:10.1021/np2000478

PMID:21486068

Abstract

Six new prenylated polyhydroxy-p-terphenyl metabolites, named prenylterphenyllins A-C (1-3) and prenylcandidusins A-C (5-7), and one new polyhydroxy-p-terphenyl with a simple tricyclic C-18 skeleton, named 4''-dehydro-3-hydroxyterphenyllin (4), were obtained together with eight known analogues (8-15) from Aspergillus taichungensis ZHN-7-07, a root soil fungus isolated from the mangrove plant Acrostichum aureum. Their structures were determined by spectroscopic methods, and their cytotoxicity was evaluated using HL-60, A-549, and P-388 cell lines. Compounds 1 and 8 exhibited moderate activities against all three cell lines (IC50 1.53-10.90 μM), whereas compounds 4 and 6 displayed moderate activities only against the P-388 cell line (IC50 of 2.70 and 1.57 μM, respectively).

摘要

六种新的倍半萜聚羟基对三联苯代谢物，命名为prenylterphenyllins A-C（1-3）和prenylcandidusins A-C（5-7），以及一种具有简单三环 C-18 骨架的新的多羟基对三联苯，命名为 4''-去氢-3-羟基对三联苯啉（4），从土壤真菌 Aspergillus taichungensis ZHN-7-07 中获得，该真菌从红树林植物 Acrostichum aureum 中分离得到。它们的结构通过光谱方法确定，并通过 HL-60、A-549 和 P-388 细胞系评估其细胞毒性。化合物 1 和 8 对所有三种细胞系均表现出中等活性（IC50 为 1.53-10.90 μM），而化合物 4 和 6 仅对 P-388 细胞系表现出中等活性（IC50 分别为 2.70 和 1.57 μM）。