Quarles R H, Sakuragawa N, Everly J L, Pasnak C F, Webster H D, Trapp B D
J Neurobiol. 1978 May;9(3):217-28. doi: 10.1002/neu.480090304.
Myelin purified from the central nervous system of Xenopus laevis contained the same major lipid and protein components as human myelin. However, some minor differences in the myelin proteins were noted. The Xenopus basic protein had a higher apparent mol wt. on sodium dodecyl sulfate gels than the corresponding mammalian protein. The absolute specific activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase in the Xenopus myelin was considerably higher than in mammals. There were differences in the high mol wt. proteins, and the glycoproteins in Xenopus myelin were more heterogeneous than those in mammals. Peripheral myelin from Xenopus sciatic nerve was compared with that from the rat. The lipids in the two types of myelin were similar. There was a major glycoprotein in the Xenopus myelin corresponding to the P0 protein and a basic protein of slightly larger mol wt. than the P1 protein of rat myelin.
从非洲爪蟾中枢神经系统纯化得到的髓磷脂所含的主要脂质和蛋白质成分与人类髓磷脂相同。然而，在髓磷脂蛋白中发现了一些细微差异。非洲爪蟾碱性蛋白在十二烷基硫酸钠凝胶上的表观分子量高于相应的哺乳动物蛋白。非洲爪蟾髓磷脂中2',3'-环核苷酸3'-磷酸水解酶的绝对比活性明显高于哺乳动物。高分子量蛋白存在差异，并且非洲爪蟾髓磷脂中的糖蛋白比哺乳动物的更具异质性。将来自非洲爪蟾坐骨神经的外周髓磷脂与大鼠的进行了比较。两种髓磷脂中的脂质相似。非洲爪蟾髓磷脂中有一种主要糖蛋白对应于P0蛋白，还有一种碱性蛋白，其分子量略大于大鼠髓磷脂的P1蛋白。
