来自半边莲的两对对映体新木脂素。
Two pairs of enantiomeric neolignans from Lobelia chinensis.
作者信息
Chen Jian-Xin, Huang Shen-Hui, Wang Lei, Han Wei-Li, Wang Ying, Zhang Dong-Mei, Ye Wen-Cai
机构信息
Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, PR China.
出版信息
Nat Prod Commun. 2010 Oct;5(10):1627-30.
A pair of new enantiomeric neolignans, ethyl 3-[(2R,3S)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl] propanoate (+) (1) and ethyl 3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl] propanoate (-) (1), together with a pair of known enantiomeric neolignans (+) (2) and (-) (2), as well as five known lignans (3-7) were isolated from the ethanol extract of Lobelia chinensis. Their structures were elucidated on the basis of extensive spectroscopic analyses, including 1D and 2D NMR, HR-ESI-MS and CD spectra.
从半边莲的乙醇提取物中分离得到一对新的对映体新木脂素，(+)-3-[(2R,3S)-2-(4-羟基-3-甲氧基苯基)-3-(羟甲基)-7-甲氧基-2,3-二氢-1-苯并呋喃-5-基]丙酸乙酯(1)和(-)-3-[(2S,3R)-2-(4-羟基-3-甲氧基苯基)-3-(羟甲基)-7-甲氧基-2,3-二氢-1-苯并呋喃-5-基]丙酸乙酯(1)，以及一对已知的对映体新木脂素(+)(2)和(-)(2)，还有五种已知木脂素(3-7)。通过广泛的光谱分析，包括一维和二维核磁共振、高分辨电喷雾电离质谱和圆二色光谱对其结构进行了阐明。
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