[狭叶柴胡根中木脂素苷类成分的研究]

[Studies on lignan glycosides from the roots of Bupleurum scorzonerifolium].

作者信息

Tan Li, Zhang Qing-ying, Li Jiao-she, Wang Bin, Tu Guang-zhong, Zhao Yu-ying

机构信息

Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.

出版信息

Yao Xue Xue Bao. 2005 May;40(5):428-31.

PMID:16220786

Abstract

AIM

To study the lignan glycosides from the roots of Bupleurum scorzonerifolium. Chromatography methods was used to isolate compounds and chemical and spectral methods were used to identify the structures of isolated compounds.

RESULTS

Two lignan glycosides were isolated from the roots of B. scorzonerifolium and their structures were identified as 2, 3-E-2,3-dihydro-2-(3'-methoxy-4'-O-beta-D-glucopyranosyl-phenyl)-3-hydroxymethyl-5-(3"-hydroxypropenyl )-7-methoxy-1-benzo [b] furan (1) and 2, 3-E-2, 3-dihydro-2-( 3'-methoxy-4'-hydroxy-phenyl)-3-hydroxymethyl-5-( 3"-hydroxypropenyl)-7-O-beta-D-glucopyranosyl-1-benzo[b]furan (2), both of them which were the mixture of (+)2S,3R- and (-)2R,3S-type diastereoisomer and in both of them the amount of (+)2S,3R-type was a little more than that of the (-)2R,3S-type.

CONCLUSION

Compounds 1 and 2 were isolated from B. scorzonerifolium for the first time. (+)2S, 3R-2, 3-Dihydro-2-(3'-methoxy-4'-hydroxy-phenyl)-3-hydroxymethyl-5-(3"-hydroxypropenyl)-7-O-beta-D-glucopyranosyl-1-benzo[b] furan is a new compound.

摘要

目的

研究狭叶柴胡根中的木脂素苷。采用色谱法分离化合物，并用化学和光谱方法鉴定分离出的化合物结构。

结果

从狭叶柴胡根中分离得到两种木脂素苷，其结构鉴定为2,3-E-2,3-二氢-2-(3'-甲氧基-4'-O-β-D-吡喃葡萄糖基苯基)-3-羟甲基-5-(3''-羟基丙烯基)-7-甲氧基-1-苯并[b]呋喃(1)和2,3-E-2,3-二氢-2-(3'-甲氧基-4'-羟基苯基)-3-羟甲基-5-(3''-羟基丙烯基)-7-O-β-D-吡喃葡萄糖基-1-苯并[b]呋喃(2)，二者均为(+)2S,3R-型和(-)2R,3S-型非对映异构体的混合物，且(+)2S,3R-型的含量略多于(-)2R,3S-型。