Global Research and Development, Baxter BioScience, 1220 Vienna, Austria.
J Virol. 2011 Feb;85(4):1896-9. doi: 10.1128/JVI.02155-10. Epub 2010 Dec 1.
West Nile virus (WNV)-neutralizing intravenous immune globulins (IVIG) were fractionated into IgG subclasses, and the contribution of each subclass to in vitro neutralization of and in vivo protection against WNV was evaluated. The results indicate that IgG1 (i) is the main subclass induced following WNV infection of humans, (ii) contained nearly all the in vitro WNV neutralization capacity, and (iii) mediates effector functions in vivo that render it superior to other subclasses in protection against WNV. The importance of human IgG1 indicates that a candidate WNV vaccine should induce an immune response that includes WNV-specific IgG1.
西尼罗河病毒（WNV）中和静脉注射免疫球蛋白（IVIG）被分成 IgG 亚类，评估了每个亚类对 WNV 的体外中和作用和体内保护作用的贡献。结果表明，IgG1（i）是人类感染 WNV 后诱导的主要亚类，（ii）包含几乎所有的体外 WNV 中和能力，（iii）介导体内效应功能，使其在保护 WNV 方面优于其他亚类。人 IgG1 的重要性表明，候选 WNV 疫苗应诱导包括 WNV 特异性 IgG1 的免疫反应。
