孕期饮用水中的高氯酸盐与加利福尼亚州新生儿甲状腺激素水平。
Perchlorate in drinking water during pregnancy and neonatal thyroid hormone levels in California.
机构信息
Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA, USA.
出版信息
J Occup Environ Med. 2010 Dec;52(12):1217-24. doi: 10.1097/JOM.0b013e3181fd6fa7.
OBJECTIVE
To evaluate associations between maternal drinking water perchlorate exposure during pregnancy and newborn thyroid hormone levels.
METHODS
Elevation in thyroid stimulating hormone (TSH), which may reflect reduced thyroxin concentration, was assessed in 497,458 newborns in California in 1998. A total of 800 perchlorate water measurements were used to classify California communities as exposed (>5 μg/L) or unexposed. Results were stratified by age at TSH collection because of the normal postbirth TSH surge, and because water sources and perchlorate exposure can change soon after birth.
RESULTS
In TSH samples collected within 24 hours of birth, the odds ratio for a TSH greater than 25 μU/mL in exposed communities was 1.53 (P < 0.0001). After 24 hours, the odds ratio for a TSH more than the 95th percentile was 1.27 (P < 0.0001).
CONCLUSION
These findings suggest that perchlorate is associated with increased neonatal TSH levels.
目的
评估孕妇怀孕期间饮用水中高氯酸盐暴露与新生儿甲状腺激素水平之间的关联。
方法
1998 年，在加利福尼亚州对 497458 名新生儿进行了促甲状腺激素（TSH）升高的评估，TSH 升高可能反映了甲状腺素浓度降低。共使用了 800 次高氯酸盐水质测量结果，将加利福尼亚州的社区分为暴露组（>5μg/L）或未暴露组。由于正常的出生后 TSH 激增，以及水源和高氯酸盐暴露可能在出生后不久发生变化，因此按 TSH 采集时的年龄对结果进行分层。
结果
在出生后 24 小时内采集的 TSH 样本中，暴露社区 TSH 大于 25μU/mL 的比值比为 1.53（P<0.0001）。24 小时后，TSH 超过第 95 百分位数的比值比为 1.27（P<0.0001）。
结论
这些发现表明，高氯酸盐与新生儿 TSH 水平升高有关。
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