Shi F T, Shi Z J, Shi H H, Lin X M, Huang Q A
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
Chin Med J (Engl). 1990 Jan;103(1):29-33.
Longitudinal surveillance was carried out consecutively during 1982-1987 in two pilot villages where bancroftian filariasis was prevalent in different severity before 1982. Intradermal test (IT) with filaria polypeptide (FPT) antigen prepared from Dirofilaria immitis was made. It was shown that the level of immediate hypersensitivity reaction to the antigen in population as shown by IT appeared to be directly proportional to both the prevalence of the disease and the infection rate of mosquitoes harbouring larval filariae before mass and selective treatment with diethylcarbamazine. Time for negative conversion of IT after chemotherapy was significantly longer in previous microfilaraemic patients than that in amicrofilaraemic cases. The selected three criteria of IT used in filariasis surveillance, namely, the positive rate, frequency of strong reaction and positive conversion rate, were diminished gradually after chemotherapy year by year, so that the three criteria were demonstrated to be useful for longitudinal surveillance of lymphatic filariasis.
1982年至1987年期间，在两个试点村庄连续开展了纵向监测。1982年前，这两个村庄班氏丝虫病流行程度不同。采用从犬恶丝虫制备的丝虫多肽（FPT）抗原进行皮内试验（IT）。结果显示，皮内试验所示人群对抗原的速发型超敏反应水平似乎与疾病流行率以及在大规模和选择性使用乙胺嗪治疗前携带丝状蚴的蚊子感染率均成正比。化疗后，既往有微丝蚴血症的患者皮内试验转阴时间明显长于无微丝蚴血症的患者。用于丝虫病监测的皮内试验选定的三项标准，即阳性率、强反应频率和转阴率，化疗后逐年逐渐降低，因此这三项标准被证明可用于淋巴丝虫病的纵向监测。
