Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA.
Opt Lett. 2010 Dec 1;35(23):3964-6. doi: 10.1364/OL.35.003964.
A near-IR (NIR) tomography system with spectral-encoded sources was built to quantify the temporal contrast in human breast tissue using guidance from magnetic resonance imaging. The systems were integrated with a custom breast coil interface to provide simultaneous acquisition. The NIR signal was synchronized to simultaneous finger pulse oximeter plethysmogram, which offered a frequency reference. A 0.1 s temporal delay of the absorption pulse within adipose tissue relative to fibroglandular tissue was found, in an initial human study, showing the potential for novel contrast imaging of fast flow signals in deep tissue.
我们构建了一个带有光谱编码源的近红外（NIR）层析成像系统，通过磁共振成像的指导来定量测量人体乳腺组织的时间对比。该系统与定制的乳腺线圈接口集成，实现了同步采集。NIR 信号与同时获取的指脉搏氧仪容积描记图同步，提供了频率参考。在初步的人体研究中，发现脂肪组织中吸收脉冲相对于纤维腺体组织存在 0.1 秒的时间延迟，这表明在深层组织中对快速流动信号进行新型对比成像具有潜力。
