Brooksby Ben, Pogue Brian W, Jiang Shudong, Dehghani Hamid, Srinivasan Subhadra, Kogel Christine, Tosteson Tor D, Weaver John, Poplack Steven P, Paulsen Keith D
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA.
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8828-33. doi: 10.1073/pnas.0509636103. Epub 2006 May 26.
Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.
磁共振（MR）引导的近红外光谱断层扫描技术已被开发出来，并用于对11名正常女性受试者的乳腺脂肪组织和纤维腺组织进行成像，这些受试者是根据机构审查委员会批准的方案招募的。重建了血红蛋白、氧饱和度、水分含量和亚细胞散射的图像，结果显示血液和水分的纤维腺组织成分比例均高于脂肪组织。在散在型和致密型乳腺类别中，个体之间脂肪和纤维腺组织组成的差异并不显著。结合磁共振和近红外断层扫描技术可提供有关这些组织类型的基本分子信息，其分辨率由磁共振T1图像决定。
