Doebbeling B N, Pfaller M A, Bale M J, Wenzel R P
Department of International Medicine, University of Iowa College of Medicine, Iowa City 52242.
Eur J Clin Microbiol Infect Dis. 1990 Apr;9(4):298-301. doi: 10.1007/BF01968067.
The in vitro activity of sparfloxacin (CI-978, AT-4140), a new quinolone which is active against gram-negative and gram-positive bacteria, and nine other broad-spectrum antibiotics was tested against 128 gram-negative nosocomial bloodstream isolates from separate patients. Sparfloxacin and ciprofloxacin were among the most potent antibiotics against Escherichia coli (n = 40), Enterobacter cloacae (n = 18), Klebsiella oxytoca (n = 13), and Klebsiella pneumoniae (n = 19), with MIC90 values of less than or equal to 0.25 microgram/ml. Ciprofloxacin was slightly more potent than sparfloxacin against Serratia marcescens (n = 14), the MIC90 values being 0.25 and 1.0 micrograms/ml respectively, although all strains were susceptible to both agents. Sparfloxacin was slightly less potent than ciprofloxacin against Pseudomonas aeruginosa (n = 24), the MIC90 values being 4.0 and 0.5 micrograms/ml respectively. Overall, the in vitro activity of sparfloxacin compared favorably with that of ciprofloxacin and the other broad spectrum agents tested against nosocomial gram-negative bloodstream isolates.
司帕沙星（CI - 978，AT - 4140）是一种对革兰氏阴性菌和革兰氏阳性菌均有活性的新型喹诺酮类药物，对来自不同患者的128株医院获得性革兰氏阴性血流感染分离株，测试了其体外活性以及其他九种广谱抗生素的活性。司帕沙星和环丙沙星是对大肠杆菌（n = 40）、阴沟肠杆菌（n = 18）、产酸克雷伯菌（n = 13）和肺炎克雷伯菌（n = 19）最有效的抗生素之一，其MIC90值小于或等于0.25微克/毫升。环丙沙星对粘质沙雷氏菌（n = 14）的活性略强于司帕沙星，其MIC90值分别为0.25和1.0微克/毫升，尽管所有菌株对这两种药物均敏感。司帕沙星对铜绿假单胞菌（n = 24）的活性略低于环丙沙星，其MIC90值分别为4.0和0.5微克/毫升。总体而言，司帕沙星的体外活性与环丙沙星以及其他针对医院获得性革兰氏阴性血流感染分离株测试的广谱药物相比具有优势。
