Hoogkamp-Korstanje J A
Department of Medical Microbiology, University Hospital St Radboud, University of Nijmegen, The Netherlands.
J Antimicrob Chemother. 1997 Sep;40(3):427-31. doi: 10.1093/jac/40.3.427.
Trovafloxacin, sparfloxacin, ciprofloxacin and levofloxacin were equally active against Moraxella catarrhalis, Haemophilus influenzae, Legionella pneumophila, Klebsiella pneumoniae, Enterobacter cloacae and Serratia marcescens. Ciprofloxacin was the most active compound against Pseudomonas aeruginosa (MIC90 = 1 mg/L), followed by trovafloxacin (MIC90 = 4 mg/L). Trovafloxacin was twice as active as sparfloxacin against Streptococcus pyogenes (MIC90 = 0.12 mg/L), Streptococcus pneumoniae (MIC90 = 0.12 mg/L) and Staphylococcus aureus (MIC90 = 0.06 mg/L) (except quinolone-resistant, methicillin-resistant S. aureus, for which the MIC90 was 8 mg/L). Trovafloxacin was the most active compound against Enterococcus faecalis: 80% of strains were susceptible to 0.25 mg/L. There was complete cross-resistance between all fluoroquinolones.
曲伐沙星、司帕沙星、环丙沙星和左氧氟沙星对卡他莫拉菌、流感嗜血杆菌、嗜肺军团菌、肺炎克雷伯菌、阴沟肠杆菌和粘质沙雷氏菌的活性相同。环丙沙星是对铜绿假单胞菌活性最强的化合物（MIC90 = 1毫克/升），其次是曲伐沙星（MIC90 = 4毫克/升）。曲伐沙星对化脓性链球菌（MIC90 = 0.12毫克/升）、肺炎链球菌（MIC90 = 0.12毫克/升）和金黄色葡萄球菌（MIC90 = 0.06毫克/升）的活性是司帕沙星的两倍（耐喹诺酮、耐甲氧西林的金黄色葡萄球菌除外，其MIC90为8毫克/升）。曲伐沙星是对粪肠球菌活性最强的化合物：80%的菌株对0.25毫克/升敏感。所有氟喹诺酮类药物之间存在完全交叉耐药性。
