Chin R K, Lao T T, Swaminathan R, Mak Y T
Department of Obstetrics and Gynaecology, Prince of Wales Hospital, Shatin, Hong Kong.
Gynecol Obstet Invest. 1990;29(1):22-5. doi: 10.1159/000293294.
Erythrocyte zinc concentration and plasma thyroid hormones were measured in 32 patients admitted to hospital because of hyperemesis gravidarum. At presentation, 8 patients had elevated total and free thyroxine concentrations. The initial erythrocyte zinc concentration in these 8 patients was not different from the others, but in 5 of them, a transient drop in the erythrocyte zinc concentration was observed 2-12 weeks later, and which returned to normal towards the end of pregnancy. The lowest erythrocyte zinc concentration in the hyperthyroxinaemic group (171.0 +/- 31.7 mumol/l of RBC) was significantly lower than that of the normothyroxinaemic group (214.2 +/- 33.9 mumol/l of RBC) (p less than 0.01). This indicates that hyperthyroxinaemia in patients with hyperemesis gravidarum represents true hyperthyroidism, but is different from classical thyrotoxicosis in that the elevation of thyroid hormones is transient.
对32例因妊娠剧吐入院的患者测定了红细胞锌浓度和血浆甲状腺激素水平。就诊时，8例患者的总甲状腺素和游离甲状腺素浓度升高。这8例患者最初的红细胞锌浓度与其他患者无差异，但其中5例在2至12周后出现红细胞锌浓度短暂下降，并在妊娠末期恢复正常。甲状腺素水平升高组的最低红细胞锌浓度（红细胞171.0±31.7μmol/L）显著低于甲状腺素水平正常组（红细胞214.2±33.9μmol/L）（p<0.01）。这表明妊娠剧吐患者的甲状腺素水平升高代表真正的甲状腺功能亢进，但与经典甲状腺毒症不同，其甲状腺激素升高是短暂的。
