Bouillon R, Naesens M, Van Assche F A, De Keyser L, De Moor P, Renaer M, De Vos P, De Roo M
Am J Obstet Gynecol. 1982 Aug 15;143(8):922-6. doi: 10.1016/0002-9378(82)90475-6.
An increased free thyroxine (T4) index was observed in 73% of 33 consecutive pregnancies complicated by severe hyperemesis gravidarum. The free triiodothyronine (T3) index was increased in only four of 11 hyperthyroxinemic patients. In five hyperthyroxinemic patients tested, no increase in serum thyrotropin was observed after the injection of thyrotropin-releasing hormone (THR). Goiter, exophthalmos, or previous history of hyperthyroidism was absent in all patients. The thyroxinemia returned to normal in one to several weeks, whether or not it was treated with antithyroid drugs. The thyroid function during the period of hyperemesis had no influence on the subsequent rate of abortion or duration of pregnancy. A lower birth weight, however, was observed in children born to hyperthyroxinemic mothers. Hyperemesis gravidarum should be included in the differential diagnosis of elevations in free T4 index during pregnancy and included in the differential diagnosis of hyperthyroidism.
在连续33例并发严重妊娠剧吐的孕妇中，73%观察到游离甲状腺素（T4）指数升高。在11例甲状腺素血症患者中，只有4例游离三碘甲状腺原氨酸（T3）指数升高。在5例接受检测的甲状腺素血症患者中，注射促甲状腺激素释放激素（TRH）后未观察到血清促甲状腺激素升高。所有患者均无甲状腺肿、突眼或既往甲亢病史。无论是否用抗甲状腺药物治疗，甲状腺素血症在1至数周内恢复正常。妊娠剧吐期间的甲状腺功能对随后的流产率或妊娠期长短没有影响。然而，甲状腺素血症母亲所生的孩子出生体重较低。妊娠剧吐应列入孕期游离T4指数升高的鉴别诊断，也应列入甲亢的鉴别诊断。
