de Barros Ana Paula Soares, Nakamura Nilton Akeshi, Santana Thiara de Freitas Borges, Motta Janaina Queiroz dos Santos, Bianchi Washington Alves
39th Rheumatology Ward, Santa Casa da Misericórdia do Rio de Janeiro.
Rev Bras Reumatol. 2010 Mar-Apr;50(2):211-6.
Relapsing polychondritis (RP) is a rare systemic disease of unknown etiology, characterized by recurrent inflammation of cartilaginous structures and other connective tissues, including the ears, nose, joints, respiratory tract, and others. Due to the presence of typical signs and symptoms, biopsy is seldom necessary. Treatment includes corticosteroids, occasionally associated with immunosuppressive agents, but refractory cases are described. Recent reports suggest that anti-TNF agents, such as infliximab, may be of value in patients who do not respond to conventional therapy, but experience with this treatment is scarce. In this paper, the authors report the case of a patient with RP refractory to combined treatment with corticosteroids and immunosuppressive agents, who showed a good response to infliximab.
复发性多软骨炎（RP）是一种病因不明的罕见全身性疾病，其特征是软骨结构和其他结缔组织反复发炎，包括耳朵、鼻子、关节、呼吸道等。由于存在典型的体征和症状，很少需要进行活检。治疗包括使用皮质类固醇，偶尔联合免疫抑制剂，但也有难治性病例的描述。最近的报告表明，抗TNF药物，如英夫利昔单抗，可能对常规治疗无反应的患者有价值，但这种治疗的经验很少。在本文中，作者报告了一例对皮质类固醇和免疫抑制剂联合治疗无效的RP患者，该患者对英夫利昔单抗表现出良好反应。
