Sugawara Takashi, Ayer Robert, Jadhav Vikram, Chen Wanqiu, Tsubokawa Tamiji, Zhang John H
Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92354, USA.
Acta Neurochir Suppl. 2011;110(Pt 2):9-11. doi: 10.1007/978-3-7091-0356-2_2.
3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent experimental evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid hemorrhage. This literature review focuses on the literature-based putative mechanisms involved in statin mediated attenuation of cerebral vasospasm, such as eNOS, vascular inflammation, apoptosis, especially the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway from our experimental study.
3-羟基-3-甲基戊二酰辅酶A（HMG CoA）还原酶抑制剂，通常称为他汀类药物，因其降脂特性而在临床上广泛使用。最近的实验证据表明，他汀类药物在改善蛛网膜下腔出血后遗症——脑血管痉挛方面也有效。这篇文献综述聚焦于基于文献的他汀类药物介导的脑血管痉挛缓解所涉及的假定机制，如内皮型一氧化氮合酶（eNOS）、血管炎症、细胞凋亡，特别是来自我们实验研究中的磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）途径。
