Sugawara T, Ayer R, Zhang J H
Department of Physiology and Pharmacology, Loma Linda University Medical School, Loma Linda, California 92354, USA.
Acta Neurochir Suppl. 2008;104:287-90. doi: 10.1007/978-3-211-75718-5_59.
3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid haemorrhage. This review focuses on the pleiotropic effects of statins, and the putative mechanisms involved in statin mediated attenuation of cerebral vasospasm.
3-羟基-3-甲基戊二酰辅酶A（HMG辅酶A）还原酶抑制剂，通常被称为他汀类药物，因其降脂特性而在临床上被广泛使用。最近的证据表明，他汀类药物在改善蛛网膜下腔出血后遗症——脑血管痉挛方面也有效。这篇综述重点关注他汀类药物的多效性作用，以及他汀类药物介导减轻脑血管痉挛的潜在机制。
