慢性病毒性肝炎患者血清中的寡克隆免疫球蛋白
Oligoclonal immunoglobulins in serum of patients with chronic viral hepatitis.
作者信息
Papadopoulos N M, Tsianos E V, Costello R
机构信息
Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
J Clin Lab Anal. 1990;4(3):180-2. doi: 10.1002/jcla.1860040306.
Zone electrophoresis on agarose gel was performed in serum samples from patients with chronic viral hepatitis. On the basis of the clinical, serological, and biochemical evaluation, the patients were divided into three categories: chronic type B hepatitis; chronic type delta hepatitis; and chronic non-A-non-B (NANB) hepatitis. The results of the electrophoretic analysis showed a high incidence of oligoclonal immunoglobulin bands (OIBs) in patients with chronic B hepatitis and chronic delta hepatitis and a low incidence of OIBs in patients with NANB. Since other biochemical and serological characteristics are variable and do not correlate with clinical symptoms of disease, we suggest that oligoclonal immunoglobulins could be used as a marker to aid in studies of the natural history and pathologic course of the various types of chronic hepatitis.
对慢性病毒性肝炎患者的血清样本进行了琼脂糖凝胶区带电泳。根据临床、血清学和生化评估，将患者分为三类：慢性乙型肝炎；慢性丁型肝炎；慢性非甲非乙型（NANB）肝炎。电泳分析结果显示，慢性乙型肝炎和慢性丁型肝炎患者中寡克隆免疫球蛋白带（OIBs）的发生率较高，而NANB肝炎患者中OIBs的发生率较低。由于其他生化和血清学特征是可变的，且与疾病的临床症状无关，我们建议寡克隆免疫球蛋白可用作一种标志物，以辅助研究各种类型慢性肝炎的自然史和病理过程。
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